Kainic acid induces mitoses in mature retinal neurones in rats

Simmons Lessell; Joseph L. Craft; Daniel M. Albert

doi:10.1016/0014-4835(80)90071-8

Kainic acid induces mitoses in mature retinal neurones in rats

Simmons Lessell, Joseph L. Craft, Daniel M. Albert

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Injection of kainic acid into the vitreous of rats causes mitoses to develop in the inner nuclear layer of the retina. The mitoses appear to be in amacrine cells. Sustained depolarization, which has been shown to be mitogenic for spinal cord neurones cultured in vitro, is presumably the mitogenic stimulus in retinal neurones exposed to kainic acid.

Original language	English (US)
Pages (from-to)	731-738
Number of pages	8
Journal	Experimental Eye Research
Volume	30
Issue number	6
DOIs	https://doi.org/10.1016/0014-4835(80)90071-8
State	Published - Jun 1980
Externally published	Yes

Keywords

amacrine cells
electron microscopy
kainic acid
mitoses
retina

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1016/0014-4835(80)90071-8

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title = "Kainic acid induces mitoses in mature retinal neurones in rats",

abstract = "Injection of kainic acid into the vitreous of rats causes mitoses to develop in the inner nuclear layer of the retina. The mitoses appear to be in amacrine cells. Sustained depolarization, which has been shown to be mitogenic for spinal cord neurones cultured in vitro, is presumably the mitogenic stimulus in retinal neurones exposed to kainic acid.",

keywords = "amacrine cells, electron microscopy, kainic acid, mitoses, retina",

author = "Simmons Lessell and Craft, {Joseph L.} and Albert, {Daniel M.}",

note = "Funding Information: The authors thank Rozanne Richman for her superb technical assistance in this investigation. This research was supported by NIH-NE1 grant 5 ROI EY 00013 Experimental Optic Keuropathies.",

year = "1980",

month = jun,

doi = "10.1016/0014-4835(80)90071-8",

language = "English (US)",

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journal = "Experimental Eye Research",

issn = "0014-4835",

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T1 - Kainic acid induces mitoses in mature retinal neurones in rats

AU - Lessell, Simmons

AU - Craft, Joseph L.

AU - Albert, Daniel M.

N1 - Funding Information: The authors thank Rozanne Richman for her superb technical assistance in this investigation. This research was supported by NIH-NE1 grant 5 ROI EY 00013 Experimental Optic Keuropathies.

PY - 1980/6

Y1 - 1980/6

N2 - Injection of kainic acid into the vitreous of rats causes mitoses to develop in the inner nuclear layer of the retina. The mitoses appear to be in amacrine cells. Sustained depolarization, which has been shown to be mitogenic for spinal cord neurones cultured in vitro, is presumably the mitogenic stimulus in retinal neurones exposed to kainic acid.

AB - Injection of kainic acid into the vitreous of rats causes mitoses to develop in the inner nuclear layer of the retina. The mitoses appear to be in amacrine cells. Sustained depolarization, which has been shown to be mitogenic for spinal cord neurones cultured in vitro, is presumably the mitogenic stimulus in retinal neurones exposed to kainic acid.

KW - amacrine cells

KW - electron microscopy

KW - kainic acid

KW - mitoses

KW - retina

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SN - 0014-4835

VL - 30

SP - 731

EP - 738

JO - Experimental Eye Research

JF - Experimental Eye Research

IS - 6

ER -

Kainic acid induces mitoses in mature retinal neurones in rats

Abstract

Keywords

ASJC Scopus subject areas

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