Kainic acid induces early and delayed degenerative neuronal changes in rat spinal cord

J. Hugon, J. M. Vallat, Peter Spencer, M. J. Leboutet, D. Barthe

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Intrathecal injections of kainic acid and sodium chloride were performed in rats to study the cellular modifications observed in spinal cord. Early neuronal changes (2 and 24 h) associated dark and shrunken or swollen and vacuolated cytoplasms. Delayed (3, 6, 14 days) changes, mainly consisted in degenerative aspect of motoneurons with eccentric and indented nucleus, swollen cytoplasms with proximal neurite enlargements, the presence of 'lipofuscin-like' pigments, disorganized intracytoplasmic organelles and filament accumulations.

Original languageEnglish (US)
Pages (from-to)258-262
Number of pages5
JournalNeuroscience Letters
Volume104
Issue number3
DOIs
StatePublished - Oct 9 1989

Fingerprint

Kainic Acid
Spinal Cord
Cytoplasm
Lipofuscin
Spinal Injections
Motor Neurons
Neurites
Sodium Chloride
Organelles

Keywords

  • Cytotoxicity
  • Excitatory amino acid
  • Kainate
  • Motoneuron

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kainic acid induces early and delayed degenerative neuronal changes in rat spinal cord. / Hugon, J.; Vallat, J. M.; Spencer, Peter; Leboutet, M. J.; Barthe, D.

In: Neuroscience Letters, Vol. 104, No. 3, 09.10.1989, p. 258-262.

Research output: Contribution to journalArticle

Hugon, J. ; Vallat, J. M. ; Spencer, Peter ; Leboutet, M. J. ; Barthe, D. / Kainic acid induces early and delayed degenerative neuronal changes in rat spinal cord. In: Neuroscience Letters. 1989 ; Vol. 104, No. 3. pp. 258-262.
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