Juxtaposition of the T-cell receptor α-chain locus (14q11) and a region (14q32) of potential importance in leukemogenesis by a 14;14 translocation in a patient with T-cell chronic lymphocytic leukemia and ataxia-telangiectasia

M. P. Davey, V. Bertness, K. Nakahara, J. P. Johnson, O. W. McBride, T. A. Waldmann, I. R. Kirsch

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Abstract

We describe a t(14;14)(q11;q32) translocation in a patient with T-cell chronic lymphocytic leukemia and ataxia-telangiectasia (AT). By using a battery of joining (J)-segment probes from the T-cell receptor (TCR) α-chain locus TCRA, three distinct J(α) rearrangements were observed. One rearrangement reflected a normal TCRA variable (V) region V(α)-to-J(α) recombination. The second rearrangement was caused by the translocation event itself, which joined a DNA segment from 14q32 centromeric to the immunoglobulin heavy chain locus (IGH) and a J(α) gene located ≃ 75 kilobases (kb) 5' of the TCRA constant region gene (C(α)). A third rearrangement involved a 17-kb internal deletion 3' to the translocation, a rearrangement within the J(α) locus that has been observed once before in a patient with AT. Analysis of these three rearrangements underscores the increase in aberrant locus-specific recombination in lymphocytes from patients with AT. Furthermore, these studies support the view that a growth-effecting gene is present in the 14q32 region that participates in the leukemogenic process.

Original languageEnglish (US)
Pages (from-to)9287-9291
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume85
Issue number23
DOIs
StatePublished - 1988

ASJC Scopus subject areas

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