Juvenile Chronic Granulocytic Leukemia: Emphasis on Cutaneous Manifestations and Underlying Neurofibromatosis

Jane A. Mays, Robert C. Neerhout, Grover C. Bagby, Robert D. Koler

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    46 Scopus citations


    Five patients with juvenile chronic granulocytic leukemia are described. Two patients had multiple cafe-au-lait spots compatible with von Recklinghausen’s neurofibromatosis, and three had cutaneous xanthomata. Recurrent cutaneous leukemic infiltrates were noted in two patients. The clinical course of all five patients was characterized by recurrent respiratory symptoms and pulmonary infiltrates that responded to antileukemic therapy in three. Chemotherapy controlled the symptoms but did not influence the eventually fatal outcome.

    Original languageEnglish (US)
    Pages (from-to)654-658
    Number of pages5
    JournalAmerican Journal of Diseases of Children
    Issue number7
    StatePublished - Jul 1980


    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health

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