Joint effect of obesity and TNFA variability on asthma: Two international cohort studies

F. Castro-Giner; M. Kogevinas; M. Imboden; R. de Cid; D. Jarvis; M. Mächler; W. Berger; P. Burney; K. A. Franklin; J. R. Gonzalez; J. Heinrich; C. Janson; E. Omenaas; I. Pin; T. Rochat; J. Sunyer; M. Wjst; J. M. Antó; X. Estivill; N. M. Probst-Hensch; M. Broglie; M. Bünter; D. Gashi; R. Armbruster; T. Damm; U. Egermann; M. Gut; L. Maier; A. Vögelin; L. Walter; D. Jud; N. Lutz; M. Ares; M. Bennour; B. Galobardes; E. Namer; B. Baumberger; S. Boccia Soldati; E. Gehrig-Van Essen; S. Ronchetto; C. Bonvin; C. Burrus; S. Blanc; A. V. Ebinger; M. L. Fragnière; J. Jordan; R. Gimmi; N. Kourkoulos; U. Schafroth; N. Bauer; D. Baehler; C. Gabriel; R. Nilly; U. Ackermann-Liebrich; J. M. Gaspoz; P. Leuenberger; L. J.S. Liu; C. Schindler; J. C. Barthélémy; R. Bettschart; A. Bircher; G. Bolognini; O. Brändli; M. Brutsche; L. Burdet; M. Frey; M. W. Gerbase; D. Gold; W. Karrer; R. Keller; B. Knöpfli; N. Künzli; U. Neu; L. Nicod; M. Pons; E. Russi; P. Schmid-Grendelmeyer; J. Schwartz; P. Straehl; J. M. Tschopp; A. von Eckardstein; J. P. Zellweger; E. Zemp Stutz; P. O. Bridevaux; I. Curjuric; S. H. Downs; D. Felber Dietrich; A. Gemperli; D. Keidel; M. Imboden; P. Staedele-Kessler; G. A. Thun; M. Abramson; R. Woods; E. H. Walters; F. Thien; G. Benke; P. Vermeire; J. Weyler; M. Van Sprundel; V. Nelen; R. Jogi; A. Soon; F. Neukirch; B. Leynaert; R. Liard; M. Zureik; I. Pin; J. Ferran-Quentin; C. Frye; I. Meyer; T. Gislason; M. Bugiani; P. Piccioni; A. Carosso; W. Arossa; E. Caria; G. Castiglioni; E. Migliore; C. Romano; D. Fabbro; G. Ciccone; C. Magnani; P. Dalmasso; R. Bono; G. Gigli; A. Giraudo; M. C. Brussino; C. Bucca; G. Rolla; R. de Marco; G. Verlato; E. Zanolin; S. Accordini; A. Poli; V. Lo Cascio; M. Ferrari; A. Marinoni; S. Villani; M. Ponzio; F. Frigerio; M. Comelli; M. Grassi; I. Cerveri; A. Corsico; J. Schouten; A. Gulsvik; C. Svanes; B. Laerum; J. P. Zock; X. Basagana; A. Jaen; F. Burgos; J. Maldonado; A. Pereira; J. L. Sanchez; J. Martinez-Moratalla Rovira; E. Almar; N. Muniozguren; I. Urritia; F. Payo; C. Janson; G. Boman; D. Norback; M. Gunnbjornsdottir; K. Toren; L. Lillienberg; A. Dahlman-Höglund; R. Sundberg; E. Norrman; M. Soderberg; K. A. Franklin; B. Lundback; B. Forsberg; L. Nystrom; B. Dibbert; M. Hazenkamp; M. Brutsche; P. Burney; S. Chinn; B. Harrison; D. Jarvis; R. Hall; D. Seaton; M. Osborne; S. Buist; W. Vollmer; L. Johnson

doi:10.1183/09031936.00140608

Joint effect of obesity and TNFA variability on asthma: Two international cohort studies

F. Castro-Giner, M. Kogevinas, M. Imboden, R. de Cid, D. Jarvis, M. Mächler, W. Berger, P. Burney, K. A. Franklin, J. R. Gonzalez, J. Heinrich, C. Janson, E. Omenaas, I. Pin, T. Rochat, J. Sunyer, M. Wjst, J. M. Antó, X. Estivill, N. M. Probst-HenschM. Broglie, M. Bünter, D. Gashi, R. Armbruster, T. Damm, U. Egermann, M. Gut, L. Maier, A. Vögelin, L. Walter, D. Jud, N. Lutz, M. Ares, M. Bennour, B. Galobardes, E. Namer, B. Baumberger, S. Boccia Soldati, E. Gehrig-Van Essen, S. Ronchetto, C. Bonvin, C. Burrus, S. Blanc, A. V. Ebinger, M. L. Fragnière, J. Jordan, R. Gimmi, N. Kourkoulos, U. Schafroth, N. Bauer, D. Baehler, C. Gabriel, R. Nilly, U. Ackermann-Liebrich, J. M. Gaspoz, P. Leuenberger, L. J.S. Liu, C. Schindler, J. C. Barthélémy, R. Bettschart, A. Bircher, G. Bolognini, O. Brändli, M. Brutsche, L. Burdet, M. Frey, M. W. Gerbase, D. Gold, W. Karrer, R. Keller, B. Knöpfli, N. Künzli, U. Neu, L. Nicod, M. Pons, E. Russi, P. Schmid-Grendelmeyer, J. Schwartz, P. Straehl, J. M. Tschopp, A. von Eckardstein, J. P. Zellweger, E. Zemp Stutz, P. O. Bridevaux, I. Curjuric, S. H. Downs, D. Felber Dietrich, A. Gemperli, D. Keidel, M. Imboden, P. Staedele-Kessler, G. A. Thun, M. Abramson, R. Woods, E. H. Walters, F. Thien, G. Benke, P. Vermeire, J. Weyler, M. Van Sprundel, V. Nelen, R. Jogi, A. Soon, F. Neukirch, B. Leynaert, R. Liard, M. Zureik, I. Pin, J. Ferran-Quentin, C. Frye, I. Meyer, T. Gislason, M. Bugiani, P. Piccioni, A. Carosso, W. Arossa, E. Caria, G. Castiglioni, E. Migliore, C. Romano, D. Fabbro, G. Ciccone, C. Magnani, P. Dalmasso, R. Bono, G. Gigli, A. Giraudo, M. C. Brussino, C. Bucca, G. Rolla, R. de Marco, G. Verlato, E. Zanolin, S. Accordini, A. Poli, V. Lo Cascio, M. Ferrari, A. Marinoni, S. Villani, M. Ponzio, F. Frigerio, M. Comelli, M. Grassi, I. Cerveri, A. Corsico, J. Schouten, A. Gulsvik, C. Svanes, B. Laerum, J. P. Zock, X. Basagana, A. Jaen, F. Burgos, J. Maldonado, A. Pereira, J. L. Sanchez, J. Martinez-Moratalla Rovira, E. Almar, N. Muniozguren, I. Urritia, F. Payo, C. Janson, G. Boman, D. Norback, M. Gunnbjornsdottir, K. Toren, L. Lillienberg, A. Dahlman-Höglund, R. Sundberg, E. Norrman, M. Soderberg, K. A. Franklin, B. Lundback, B. Forsberg, L. Nystrom, B. Dibbert, M. Hazenkamp, M. Brutsche, P. Burney, S. Chinn, B. Harrison, D. Jarvis, R. Hall, D. Seaton, M. Osborne, S. Buist, W. Vollmer, L. Johnson

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Obesity is a risk factor for asthma. Adipose tissue expresses pro-inflammatory molecules including tumour necrosis factor (TNF), and levels of TNF are also related to polymorphisms in the TNF-a (TNFA) gene. The current authors examined the joint effect of obesity and TNFA variability on asthma in adults by combining two population-based studies. The European Community Respiratory Health Survey and the Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults used comparable protocols, questionnaires and measures of lung function and atopy. DNA samples from 9,167 participants were genotyped for TNFA -308 and lymphotoxin-a (LTA) +252 gene variants. Obesity and TNFA were associated with asthma when mutually adjusting for their independent effects (odds ratio (OR) for obesity 2.4, 95% confidence interval (CI) 1.7-3.2; OR for TNFA -308 polymorphism 1.3, 95% CI 1.1-1.6). The association of obesity with asthma was stronger for subjects carrying the G/A and A/A TNFA -308 genotypes compared with the more common G/G genotype, particularly among nonatopics (OR for G/A and A/A genotypes 6.1, 95% CI 2.5-14.4; OR for G/G genotype 1.7, 95% CI 0.8-3.3). The present findings provide, for the first time, evidence for a complex pattern of interaction between obesity, a pro-inflammatory genetic factor and asthma.

Original language	English (US)
Pages (from-to)	1003-1009
Number of pages	7
Journal	European Respiratory Journal
Volume	33
Issue number	5
DOIs	https://doi.org/10.1183/09031936.00140608
State	Published - May 2009
Externally published	Yes

Keywords

Asthma
Atopy
Genetic polymorphism
Obesity
Tumour necrosis factor-a

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Access to Document

10.1183/09031936.00140608

Cite this

Castro-Giner, F., Kogevinas, M., Imboden, M., de Cid, R., Jarvis, D., Mächler, M., Berger, W., Burney, P., Franklin, K. A., Gonzalez, J. R., Heinrich, J., Janson, C., Omenaas, E., Pin, I., Rochat, T., Sunyer, J., Wjst, M., Antó, J. M., Estivill, X., ... Johnson, L. (2009). Joint effect of obesity and TNFA variability on asthma: Two international cohort studies. European Respiratory Journal, 33(5), 1003-1009. https://doi.org/10.1183/09031936.00140608

Castro-Giner, F, Kogevinas, M, Imboden, M, de Cid, R, Jarvis, D, Mächler, M, Berger, W, Burney, P, Franklin, KA, Gonzalez, JR, Heinrich, J, Janson, C, Omenaas, E, Pin, I, Rochat, T, Sunyer, J, Wjst, M, Antó, JM, Estivill, X, Probst-Hensch, NM, Broglie, M, Bünter, M, Gashi, D, Armbruster, R, Damm, T, Egermann, U, Gut, M, Maier, L, Vögelin, A, Walter, L, Jud, D, Lutz, N, Ares, M, Bennour, M, Galobardes, B, Namer, E, Baumberger, B, Boccia Soldati, S, Gehrig-Van Essen, E, Ronchetto, S, Bonvin, C, Burrus, C, Blanc, S, Ebinger, AV, Fragnière, ML, Jordan, J, Gimmi, R, Kourkoulos, N, Schafroth, U, Bauer, N, Baehler, D, Gabriel, C, Nilly, R, Ackermann-Liebrich, U, Gaspoz, JM, Leuenberger, P, Liu, LJS, Schindler, C, Barthélémy, JC, Bettschart, R, Bircher, A, Bolognini, G, Brändli, O, Brutsche, M, Burdet, L, Frey, M, Gerbase, MW, Gold, D, Karrer, W, Keller, R, Knöpfli, B, Künzli, N, Neu, U, Nicod, L, Pons, M, Russi, E, Schmid-Grendelmeyer, P, Schwartz, J, Straehl, P, Tschopp, JM, von Eckardstein, A, Zellweger, JP, Zemp Stutz, E, Bridevaux, PO, Curjuric, I, Downs, SH, Felber Dietrich, D, Gemperli, A, Keidel, D, Imboden, M, Staedele-Kessler, P, Thun, GA, Abramson, M, Woods, R, Walters, EH, Thien, F, Benke, G, Vermeire, P, Weyler, J, Van Sprundel, M, Nelen, V, Jogi, R, Soon, A, Neukirch, F, Leynaert, B, Liard, R, Zureik, M, Pin, I, Ferran-Quentin, J, Frye, C, Meyer, I, Gislason, T, Bugiani, M, Piccioni, P, Carosso, A, Arossa, W, Caria, E, Castiglioni, G, Migliore, E, Romano, C, Fabbro, D, Ciccone, G, Magnani, C, Dalmasso, P, Bono, R, Gigli, G, Giraudo, A, Brussino, MC, Bucca, C, Rolla, G, de Marco, R, Verlato, G, Zanolin, E, Accordini, S, Poli, A, Lo Cascio, V, Ferrari, M, Marinoni, A, Villani, S, Ponzio, M, Frigerio, F, Comelli, M, Grassi, M, Cerveri, I, Corsico, A, Schouten, J, Gulsvik, A, Svanes, C, Laerum, B, Zock, JP, Basagana, X, Jaen, A, Burgos, F, Maldonado, J, Pereira, A, Sanchez, JL, Martinez-Moratalla Rovira, J, Almar, E, Muniozguren, N, Urritia, I, Payo, F, Janson, C, Boman, G, Norback, D, Gunnbjornsdottir, M, Toren, K, Lillienberg, L, Dahlman-Höglund, A, Sundberg, R, Norrman, E, Soderberg, M, Franklin, KA, Lundback, B, Forsberg, B, Nystrom, L, Dibbert, B, Hazenkamp, M, Brutsche, M, Burney, P, Chinn, S, Harrison, B, Jarvis, D, Hall, R, Seaton, D, Osborne, M, Buist, S, Vollmer, W & Johnson, L 2009, 'Joint effect of obesity and TNFA variability on asthma: Two international cohort studies', European Respiratory Journal, vol. 33, no. 5, pp. 1003-1009. https://doi.org/10.1183/09031936.00140608

@article{897fd4dbef1a41c983e0be47a829b26a,

title = "Joint effect of obesity and TNFA variability on asthma: Two international cohort studies",

abstract = "Obesity is a risk factor for asthma. Adipose tissue expresses pro-inflammatory molecules including tumour necrosis factor (TNF), and levels of TNF are also related to polymorphisms in the TNF-a (TNFA) gene. The current authors examined the joint effect of obesity and TNFA variability on asthma in adults by combining two population-based studies. The European Community Respiratory Health Survey and the Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults used comparable protocols, questionnaires and measures of lung function and atopy. DNA samples from 9,167 participants were genotyped for TNFA -308 and lymphotoxin-a (LTA) +252 gene variants. Obesity and TNFA were associated with asthma when mutually adjusting for their independent effects (odds ratio (OR) for obesity 2.4, 95% confidence interval (CI) 1.7-3.2; OR for TNFA -308 polymorphism 1.3, 95% CI 1.1-1.6). The association of obesity with asthma was stronger for subjects carrying the G/A and A/A TNFA -308 genotypes compared with the more common G/G genotype, particularly among nonatopics (OR for G/A and A/A genotypes 6.1, 95% CI 2.5-14.4; OR for G/G genotype 1.7, 95% CI 0.8-3.3). The present findings provide, for the first time, evidence for a complex pattern of interaction between obesity, a pro-inflammatory genetic factor and asthma.",

keywords = "Asthma, Atopy, Genetic polymorphism, Obesity, Tumour necrosis factor-a",

author = "F. Castro-Giner and M. Kogevinas and M. Imboden and {de Cid}, R. and D. Jarvis and M. M{\"a}chler and W. Berger and P. Burney and Franklin, {K. A.} and Gonzalez, {J. R.} and J. Heinrich and C. Janson and E. Omenaas and I. Pin and T. Rochat and J. Sunyer and M. Wjst and Ant{\'o}, {J. M.} and X. Estivill and Probst-Hensch, {N. M.} and M. Broglie and M. B{\"u}nter and D. Gashi and R. Armbruster and T. Damm and U. Egermann and M. Gut and L. Maier and A. V{\"o}gelin and L. Walter and D. Jud and N. Lutz and M. Ares and M. Bennour and B. Galobardes and E. Namer and B. Baumberger and {Boccia Soldati}, S. and {Gehrig-Van Essen}, E. and S. Ronchetto and C. Bonvin and C. Burrus and S. Blanc and Ebinger, {A. V.} and Fragni{\`e}re, {M. L.} and J. Jordan and R. Gimmi and N. Kourkoulos and U. Schafroth and N. Bauer and D. Baehler and C. Gabriel and R. Nilly and U. Ackermann-Liebrich and Gaspoz, {J. M.} and P. Leuenberger and Liu, {L. J.S.} and C. Schindler and Barth{\'e}l{\'e}my, {J. C.} and R. Bettschart and A. Bircher and G. Bolognini and O. Br{\"a}ndli and M. Brutsche and L. Burdet and M. Frey and Gerbase, {M. W.} and D. Gold and W. Karrer and R. Keller and B. Kn{\"o}pfli and N. K{\"u}nzli and U. Neu and L. Nicod and M. Pons and E. Russi and P. Schmid-Grendelmeyer and J. Schwartz and P. Straehl and Tschopp, {J. M.} and {von Eckardstein}, A. and Zellweger, {J. P.} and {Zemp Stutz}, E. and Bridevaux, {P. O.} and I. Curjuric and Downs, {S. H.} and {Felber Dietrich}, D. and A. Gemperli and D. Keidel and M. Imboden and P. Staedele-Kessler and Thun, {G. A.} and M. Abramson and R. Woods and Walters, {E. H.} and F. Thien and G. Benke and P. Vermeire and J. Weyler and {Van Sprundel}, M. and V. Nelen and R. Jogi and A. Soon and F. Neukirch and B. Leynaert and R. Liard and M. Zureik and I. Pin and J. Ferran-Quentin and C. Frye and I. Meyer and T. Gislason and M. Bugiani and P. Piccioni and A. Carosso and W. Arossa and E. Caria and G. Castiglioni and E. Migliore and C. Romano and D. Fabbro and G. Ciccone and C. Magnani and P. Dalmasso and R. Bono and G. Gigli and A. Giraudo and Brussino, {M. C.} and C. Bucca and G. Rolla and {de Marco}, R. and G. Verlato and E. Zanolin and S. Accordini and A. Poli and {Lo Cascio}, V. and M. Ferrari and A. Marinoni and S. Villani and M. Ponzio and F. Frigerio and M. Comelli and M. Grassi and I. Cerveri and A. Corsico and J. Schouten and A. Gulsvik and C. Svanes and B. Laerum and Zock, {J. P.} and X. Basagana and A. Jaen and F. Burgos and J. Maldonado and A. Pereira and Sanchez, {J. L.} and {Martinez-Moratalla Rovira}, J. and E. Almar and N. Muniozguren and I. Urritia and F. Payo and C. Janson and G. Boman and D. Norback and M. Gunnbjornsdottir and K. Toren and L. Lillienberg and A. Dahlman-H{\"o}glund and R. Sundberg and E. Norrman and M. Soderberg and Franklin, {K. A.} and B. Lundback and B. Forsberg and L. Nystrom and B. Dibbert and M. Hazenkamp and M. Brutsche and P. Burney and S. Chinn and B. Harrison and D. Jarvis and R. Hall and D. Seaton and M. Osborne and S. Buist and W. Vollmer and L. Johnson",

year = "2009",

month = may,

doi = "10.1183/09031936.00140608",

language = "English (US)",

volume = "33",

pages = "1003--1009",

journal = "The European respiratory journal",

issn = "0903-1936",

number = "5",

}

TY - JOUR

T1 - Joint effect of obesity and TNFA variability on asthma

T2 - Two international cohort studies

AU - Castro-Giner, F.

AU - Kogevinas, M.

AU - Imboden, M.

AU - de Cid, R.

AU - Jarvis, D.

AU - Mächler, M.

AU - Berger, W.

AU - Burney, P.

AU - Franklin, K. A.

AU - Gonzalez, J. R.

AU - Heinrich, J.

AU - Janson, C.

AU - Omenaas, E.

AU - Pin, I.

AU - Rochat, T.

AU - Sunyer, J.

AU - Wjst, M.

AU - Antó, J. M.

AU - Estivill, X.

AU - Probst-Hensch, N. M.

AU - Broglie, M.

AU - Bünter, M.

AU - Gashi, D.

AU - Armbruster, R.

AU - Damm, T.

AU - Egermann, U.

AU - Gut, M.

AU - Maier, L.

AU - Vögelin, A.

AU - Walter, L.

AU - Jud, D.

AU - Lutz, N.

AU - Ares, M.

AU - Bennour, M.

AU - Galobardes, B.

AU - Namer, E.

AU - Baumberger, B.

AU - Boccia Soldati, S.

AU - Gehrig-Van Essen, E.

AU - Ronchetto, S.

AU - Bonvin, C.

AU - Burrus, C.

AU - Blanc, S.

AU - Ebinger, A. V.

AU - Fragnière, M. L.

AU - Jordan, J.

AU - Gimmi, R.

AU - Kourkoulos, N.

AU - Schafroth, U.

AU - Bauer, N.

AU - Baehler, D.

AU - Gabriel, C.

AU - Nilly, R.

AU - Ackermann-Liebrich, U.

AU - Gaspoz, J. M.

AU - Leuenberger, P.

AU - Liu, L. J.S.

AU - Schindler, C.

AU - Barthélémy, J. C.

AU - Bettschart, R.

AU - Bircher, A.

AU - Bolognini, G.

AU - Brändli, O.

AU - Brutsche, M.

AU - Burdet, L.

AU - Frey, M.

AU - Gerbase, M. W.

AU - Gold, D.

AU - Karrer, W.

AU - Keller, R.

AU - Knöpfli, B.

AU - Künzli, N.

AU - Neu, U.

AU - Nicod, L.

AU - Pons, M.

AU - Russi, E.

AU - Schmid-Grendelmeyer, P.

AU - Schwartz, J.

AU - Straehl, P.

AU - Tschopp, J. M.

AU - von Eckardstein, A.

AU - Zellweger, J. P.

AU - Zemp Stutz, E.

AU - Bridevaux, P. O.

AU - Curjuric, I.

AU - Downs, S. H.

AU - Felber Dietrich, D.

AU - Gemperli, A.

AU - Keidel, D.

AU - Imboden, M.

AU - Staedele-Kessler, P.

AU - Thun, G. A.

AU - Abramson, M.

AU - Woods, R.

AU - Walters, E. H.

AU - Thien, F.

AU - Benke, G.

AU - Vermeire, P.

AU - Weyler, J.

AU - Van Sprundel, M.

AU - Nelen, V.

AU - Jogi, R.

AU - Soon, A.

AU - Neukirch, F.

AU - Leynaert, B.

AU - Liard, R.

AU - Zureik, M.

AU - Pin, I.

AU - Ferran-Quentin, J.

AU - Frye, C.

AU - Meyer, I.

AU - Gislason, T.

AU - Bugiani, M.

AU - Piccioni, P.

AU - Carosso, A.

AU - Arossa, W.

AU - Caria, E.

AU - Castiglioni, G.

AU - Migliore, E.

AU - Romano, C.

AU - Fabbro, D.

AU - Ciccone, G.

AU - Magnani, C.

AU - Dalmasso, P.

AU - Bono, R.

AU - Gigli, G.

AU - Giraudo, A.

AU - Brussino, M. C.

AU - Bucca, C.

AU - Rolla, G.

AU - de Marco, R.

AU - Verlato, G.

AU - Zanolin, E.

AU - Accordini, S.

AU - Poli, A.

AU - Lo Cascio, V.

AU - Ferrari, M.

AU - Marinoni, A.

AU - Villani, S.

AU - Ponzio, M.

AU - Frigerio, F.

AU - Comelli, M.

AU - Grassi, M.

AU - Cerveri, I.

AU - Corsico, A.

AU - Schouten, J.

AU - Gulsvik, A.

AU - Svanes, C.

AU - Laerum, B.

AU - Zock, J. P.

AU - Basagana, X.

AU - Jaen, A.

AU - Burgos, F.

AU - Maldonado, J.

AU - Pereira, A.

AU - Sanchez, J. L.

AU - Martinez-Moratalla Rovira, J.

AU - Almar, E.

AU - Muniozguren, N.

AU - Urritia, I.

AU - Payo, F.

AU - Janson, C.

AU - Boman, G.

AU - Norback, D.

AU - Gunnbjornsdottir, M.

AU - Toren, K.

AU - Lillienberg, L.

AU - Dahlman-Höglund, A.

AU - Sundberg, R.

AU - Norrman, E.

AU - Soderberg, M.

AU - Franklin, K. A.

AU - Lundback, B.

AU - Forsberg, B.

AU - Nystrom, L.

AU - Dibbert, B.

AU - Hazenkamp, M.

AU - Brutsche, M.

AU - Burney, P.

AU - Chinn, S.

AU - Harrison, B.

AU - Jarvis, D.

AU - Hall, R.

AU - Seaton, D.

AU - Osborne, M.

AU - Buist, S.

AU - Vollmer, W.

AU - Johnson, L.

PY - 2009/5

Y1 - 2009/5

N2 - Obesity is a risk factor for asthma. Adipose tissue expresses pro-inflammatory molecules including tumour necrosis factor (TNF), and levels of TNF are also related to polymorphisms in the TNF-a (TNFA) gene. The current authors examined the joint effect of obesity and TNFA variability on asthma in adults by combining two population-based studies. The European Community Respiratory Health Survey and the Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults used comparable protocols, questionnaires and measures of lung function and atopy. DNA samples from 9,167 participants were genotyped for TNFA -308 and lymphotoxin-a (LTA) +252 gene variants. Obesity and TNFA were associated with asthma when mutually adjusting for their independent effects (odds ratio (OR) for obesity 2.4, 95% confidence interval (CI) 1.7-3.2; OR for TNFA -308 polymorphism 1.3, 95% CI 1.1-1.6). The association of obesity with asthma was stronger for subjects carrying the G/A and A/A TNFA -308 genotypes compared with the more common G/G genotype, particularly among nonatopics (OR for G/A and A/A genotypes 6.1, 95% CI 2.5-14.4; OR for G/G genotype 1.7, 95% CI 0.8-3.3). The present findings provide, for the first time, evidence for a complex pattern of interaction between obesity, a pro-inflammatory genetic factor and asthma.

AB - Obesity is a risk factor for asthma. Adipose tissue expresses pro-inflammatory molecules including tumour necrosis factor (TNF), and levels of TNF are also related to polymorphisms in the TNF-a (TNFA) gene. The current authors examined the joint effect of obesity and TNFA variability on asthma in adults by combining two population-based studies. The European Community Respiratory Health Survey and the Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults used comparable protocols, questionnaires and measures of lung function and atopy. DNA samples from 9,167 participants were genotyped for TNFA -308 and lymphotoxin-a (LTA) +252 gene variants. Obesity and TNFA were associated with asthma when mutually adjusting for their independent effects (odds ratio (OR) for obesity 2.4, 95% confidence interval (CI) 1.7-3.2; OR for TNFA -308 polymorphism 1.3, 95% CI 1.1-1.6). The association of obesity with asthma was stronger for subjects carrying the G/A and A/A TNFA -308 genotypes compared with the more common G/G genotype, particularly among nonatopics (OR for G/A and A/A genotypes 6.1, 95% CI 2.5-14.4; OR for G/G genotype 1.7, 95% CI 0.8-3.3). The present findings provide, for the first time, evidence for a complex pattern of interaction between obesity, a pro-inflammatory genetic factor and asthma.

KW - Asthma

KW - Atopy

KW - Genetic polymorphism

KW - Obesity

KW - Tumour necrosis factor-a

UR - http://www.scopus.com/inward/record.url?scp=66749175772&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66749175772&partnerID=8YFLogxK

U2 - 10.1183/09031936.00140608

DO - 10.1183/09031936.00140608

M3 - Article

C2 - 19196817

AN - SCOPUS:66749175772

VL - 33

SP - 1003

EP - 1009

JO - The European respiratory journal

JF - The European respiratory journal

SN - 0903-1936

IS - 5

ER -

Joint effect of obesity and TNFA variability on asthma: Two international cohort studies

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