Abstract
Obesity is a risk factor for asthma. Adipose tissue expresses pro-inflammatory molecules including tumour necrosis factor (TNF), and levels of TNF are also related to polymorphisms in the TNF-a (TNFA) gene. The current authors examined the joint effect of obesity and TNFA variability on asthma in adults by combining two population-based studies. The European Community Respiratory Health Survey and the Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults used comparable protocols, questionnaires and measures of lung function and atopy. DNA samples from 9,167 participants were genotyped for TNFA -308 and lymphotoxin-a (LTA) +252 gene variants. Obesity and TNFA were associated with asthma when mutually adjusting for their independent effects (odds ratio (OR) for obesity 2.4, 95% confidence interval (CI) 1.7-3.2; OR for TNFA -308 polymorphism 1.3, 95% CI 1.1-1.6). The association of obesity with asthma was stronger for subjects carrying the G/A and A/A TNFA -308 genotypes compared with the more common G/G genotype, particularly among nonatopics (OR for G/A and A/A genotypes 6.1, 95% CI 2.5-14.4; OR for G/G genotype 1.7, 95% CI 0.8-3.3). The present findings provide, for the first time, evidence for a complex pattern of interaction between obesity, a pro-inflammatory genetic factor and asthma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1003-1009 |
| Number of pages | 7 |
| Journal | European Respiratory Journal |
| Volume | 33 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2009 |
| Externally published | Yes |
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Keywords
- Asthma
- Atopy
- Genetic polymorphism
- Obesity
- Tumour necrosis factor-a
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Joint effect of obesity and TNFA variability on asthma : Two international cohort studies. / Castro-Giner, F.; Kogevinas, M.; Imboden, M.; de Cid, R.; Jarvis, D.; Mächler, M.; Berger, W.; Burney, P.; Franklin, K. A.; Gonzalez, J. R.; Heinrich, J.; Janson, C.; Omenaas, E.; Pin, I.; Rochat, T.; Sunyer, J.; Wjst, M.; Antó, J. M.; Estivill, X.; Probst-Hensch, N. M.; Broglie, M.; Bünter, M.; Gashi, D.; Armbruster, R.; Damm, T.; Egermann, U.; Gut, M.; Maier, L.; Vögelin, A.; Walter, L.; Jud, D.; Lutz, N.; Ares, M.; Bennour, M.; Galobardes, B.; Namer, E.; Baumberger, B.; Boccia Soldati, S.; Gehrig-Van Essen, E.; Ronchetto, S.; Bonvin, C.; Burrus, C.; Blanc, S.; Ebinger, A. V.; Fragnière, M. L.; Jordan, J.; Gimmi, R.; Kourkoulos, N.; Schafroth, U.; Bauer, N.; Baehler, D.; Gabriel, C.; Nilly, R.; Ackermann-Liebrich, U.; Gaspoz, J. M.; Leuenberger, P.; Liu, L. J S; Schindler, C.; Barthélémy, J. C.; Bettschart, R.; Bircher, A.; Bolognini, G.; Brändli, O.; Brutsche, M.; Burdet, L.; Frey, M.; Gerbase, M. W.; Gold, D.; Karrer, W.; Keller, R.; Knöpfli, B.; Künzli, N.; Neu, U.; Nicod, L.; Pons, M.; Russi, E.; Schmid-Grendelmeyer, P.; Schwartz, J.; Straehl, P.; Tschopp, J. M.; von Eckardstein, A.; Zellweger, J. P.; Zemp Stutz, E.; Bridevaux, P. O.; Curjuric, I.; Downs, S. H.; Felber Dietrich, D.; Gemperli, A.; Keidel, D.; Imboden, M.; Staedele-Kessler, P.; Thun, G. A.; Abramson, M.; Woods, R.; Walters, E. H.; Thien, F.; Benke, G.; Vermeire, P.; Weyler, J.; Van Sprundel, M.; Nelen, V.; Jogi, R.; Soon, A.; Neukirch, F.; Leynaert, B.; Liard, R.; Zureik, M.; Pin, I.; Ferran-Quentin, J.; Heinrich, J.; Frye, C.; Meyer, I.; Gislason, T.; Bugiani, M.; Piccioni, P.; Carosso, A.; Arossa, W.; Caria, E.; Castiglioni, G.; Migliore, E.; Romano, C.; Fabbro, D.; Ciccone, G.; Magnani, C.; Dalmasso, P.; Bono, R.; Gigli, G.; Giraudo, A.; Brussino, M. C.; Bucca, C.; Rolla, G.; de Marco, R.; Verlato, G.; Zanolin, E.; Accordini, S.; Poli, A.; Lo Cascio, V.; Ferrari, M.; Marinoni, A.; Villani, S.; Ponzio, M.; Frigerio, F.; Comelli, M.; Grassi, M.; Cerveri, I.; Corsico, A.; Schouten, J.; Gulsvik, A.; Svanes, C.; Laerum, B.; Zock, J. P.; Basagana, X.; Jaen, A.; Burgos, F.; Maldonado, J.; Pereira, A.; Sanchez, J. L.; Martinez-Moratalla Rovira, J.; Almar, E.; Muniozguren, N.; Urritia, I.; Payo, F.; Janson, C.; Boman, G.; Norback, D.; Gunnbjornsdottir, M.; Toren, K.; Lillienberg, L.; Dahlman-Höglund, A.; Sundberg, R.; Norrman, E.; Soderberg, M.; Franklin, K. A.; Lundback, B.; Forsberg, B.; Nystrom, L.; Dibbert, B.; Hazenkamp, M.; Brutsche, M.; Burney, P.; Chinn, S.; Harrison, B.; Jarvis, D.; Hall, R.; Seaton, D.; Osborne, Molly; Buist, A (Sonia); Vollmer, W.; Johnson, L.
In: European Respiratory Journal, Vol. 33, No. 5, 05.2009, p. 1003-1009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Joint effect of obesity and TNFA variability on asthma
T2 - Two international cohort studies
AU - Castro-Giner, F.
AU - Kogevinas, M.
AU - Imboden, M.
AU - de Cid, R.
AU - Jarvis, D.
AU - Mächler, M.
AU - Berger, W.
AU - Burney, P.
AU - Franklin, K. A.
AU - Gonzalez, J. R.
AU - Heinrich, J.
AU - Janson, C.
AU - Omenaas, E.
AU - Pin, I.
AU - Rochat, T.
AU - Sunyer, J.
AU - Wjst, M.
AU - Antó, J. M.
AU - Estivill, X.
AU - Probst-Hensch, N. M.
AU - Broglie, M.
AU - Bünter, M.
AU - Gashi, D.
AU - Armbruster, R.
AU - Damm, T.
AU - Egermann, U.
AU - Gut, M.
AU - Maier, L.
AU - Vögelin, A.
AU - Walter, L.
AU - Jud, D.
AU - Lutz, N.
AU - Ares, M.
AU - Bennour, M.
AU - Galobardes, B.
AU - Namer, E.
AU - Baumberger, B.
AU - Boccia Soldati, S.
AU - Gehrig-Van Essen, E.
AU - Ronchetto, S.
AU - Bonvin, C.
AU - Burrus, C.
AU - Blanc, S.
AU - Ebinger, A. V.
AU - Fragnière, M. L.
AU - Jordan, J.
AU - Gimmi, R.
AU - Kourkoulos, N.
AU - Schafroth, U.
AU - Bauer, N.
AU - Baehler, D.
AU - Gabriel, C.
AU - Nilly, R.
AU - Ackermann-Liebrich, U.
AU - Gaspoz, J. M.
AU - Leuenberger, P.
AU - Liu, L. J S
AU - Schindler, C.
AU - Barthélémy, J. C.
AU - Bettschart, R.
AU - Bircher, A.
AU - Bolognini, G.
AU - Brändli, O.
AU - Brutsche, M.
AU - Burdet, L.
AU - Frey, M.
AU - Gerbase, M. W.
AU - Gold, D.
AU - Karrer, W.
AU - Keller, R.
AU - Knöpfli, B.
AU - Künzli, N.
AU - Neu, U.
AU - Nicod, L.
AU - Pons, M.
AU - Russi, E.
AU - Schmid-Grendelmeyer, P.
AU - Schwartz, J.
AU - Straehl, P.
AU - Tschopp, J. M.
AU - von Eckardstein, A.
AU - Zellweger, J. P.
AU - Zemp Stutz, E.
AU - Bridevaux, P. O.
AU - Curjuric, I.
AU - Downs, S. H.
AU - Felber Dietrich, D.
AU - Gemperli, A.
AU - Keidel, D.
AU - Imboden, M.
AU - Staedele-Kessler, P.
AU - Thun, G. A.
AU - Abramson, M.
AU - Woods, R.
AU - Walters, E. H.
AU - Thien, F.
AU - Benke, G.
AU - Vermeire, P.
AU - Weyler, J.
AU - Van Sprundel, M.
AU - Nelen, V.
AU - Jogi, R.
AU - Soon, A.
AU - Neukirch, F.
AU - Leynaert, B.
AU - Liard, R.
AU - Zureik, M.
AU - Pin, I.
AU - Ferran-Quentin, J.
AU - Heinrich, J.
AU - Frye, C.
AU - Meyer, I.
AU - Gislason, T.
AU - Bugiani, M.
AU - Piccioni, P.
AU - Carosso, A.
AU - Arossa, W.
AU - Caria, E.
AU - Castiglioni, G.
AU - Migliore, E.
AU - Romano, C.
AU - Fabbro, D.
AU - Ciccone, G.
AU - Magnani, C.
AU - Dalmasso, P.
AU - Bono, R.
AU - Gigli, G.
AU - Giraudo, A.
AU - Brussino, M. C.
AU - Bucca, C.
AU - Rolla, G.
AU - de Marco, R.
AU - Verlato, G.
AU - Zanolin, E.
AU - Accordini, S.
AU - Poli, A.
AU - Lo Cascio, V.
AU - Ferrari, M.
AU - Marinoni, A.
AU - Villani, S.
AU - Ponzio, M.
AU - Frigerio, F.
AU - Comelli, M.
AU - Grassi, M.
AU - Cerveri, I.
AU - Corsico, A.
AU - Schouten, J.
AU - Gulsvik, A.
AU - Svanes, C.
AU - Laerum, B.
AU - Zock, J. P.
AU - Basagana, X.
AU - Jaen, A.
AU - Burgos, F.
AU - Maldonado, J.
AU - Pereira, A.
AU - Sanchez, J. L.
AU - Martinez-Moratalla Rovira, J.
AU - Almar, E.
AU - Muniozguren, N.
AU - Urritia, I.
AU - Payo, F.
AU - Janson, C.
AU - Boman, G.
AU - Norback, D.
AU - Gunnbjornsdottir, M.
AU - Toren, K.
AU - Lillienberg, L.
AU - Dahlman-Höglund, A.
AU - Sundberg, R.
AU - Norrman, E.
AU - Soderberg, M.
AU - Franklin, K. A.
AU - Lundback, B.
AU - Forsberg, B.
AU - Nystrom, L.
AU - Dibbert, B.
AU - Hazenkamp, M.
AU - Brutsche, M.
AU - Burney, P.
AU - Chinn, S.
AU - Harrison, B.
AU - Jarvis, D.
AU - Hall, R.
AU - Seaton, D.
AU - Osborne, Molly
AU - Buist, A (Sonia)
AU - Vollmer, W.
AU - Johnson, L.
PY - 2009/5
Y1 - 2009/5
N2 - Obesity is a risk factor for asthma. Adipose tissue expresses pro-inflammatory molecules including tumour necrosis factor (TNF), and levels of TNF are also related to polymorphisms in the TNF-a (TNFA) gene. The current authors examined the joint effect of obesity and TNFA variability on asthma in adults by combining two population-based studies. The European Community Respiratory Health Survey and the Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults used comparable protocols, questionnaires and measures of lung function and atopy. DNA samples from 9,167 participants were genotyped for TNFA -308 and lymphotoxin-a (LTA) +252 gene variants. Obesity and TNFA were associated with asthma when mutually adjusting for their independent effects (odds ratio (OR) for obesity 2.4, 95% confidence interval (CI) 1.7-3.2; OR for TNFA -308 polymorphism 1.3, 95% CI 1.1-1.6). The association of obesity with asthma was stronger for subjects carrying the G/A and A/A TNFA -308 genotypes compared with the more common G/G genotype, particularly among nonatopics (OR for G/A and A/A genotypes 6.1, 95% CI 2.5-14.4; OR for G/G genotype 1.7, 95% CI 0.8-3.3). The present findings provide, for the first time, evidence for a complex pattern of interaction between obesity, a pro-inflammatory genetic factor and asthma.
AB - Obesity is a risk factor for asthma. Adipose tissue expresses pro-inflammatory molecules including tumour necrosis factor (TNF), and levels of TNF are also related to polymorphisms in the TNF-a (TNFA) gene. The current authors examined the joint effect of obesity and TNFA variability on asthma in adults by combining two population-based studies. The European Community Respiratory Health Survey and the Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults used comparable protocols, questionnaires and measures of lung function and atopy. DNA samples from 9,167 participants were genotyped for TNFA -308 and lymphotoxin-a (LTA) +252 gene variants. Obesity and TNFA were associated with asthma when mutually adjusting for their independent effects (odds ratio (OR) for obesity 2.4, 95% confidence interval (CI) 1.7-3.2; OR for TNFA -308 polymorphism 1.3, 95% CI 1.1-1.6). The association of obesity with asthma was stronger for subjects carrying the G/A and A/A TNFA -308 genotypes compared with the more common G/G genotype, particularly among nonatopics (OR for G/A and A/A genotypes 6.1, 95% CI 2.5-14.4; OR for G/G genotype 1.7, 95% CI 0.8-3.3). The present findings provide, for the first time, evidence for a complex pattern of interaction between obesity, a pro-inflammatory genetic factor and asthma.
KW - Asthma
KW - Atopy
KW - Genetic polymorphism
KW - Obesity
KW - Tumour necrosis factor-a
UR - http://www.scopus.com/inward/record.url?scp=66749175772&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66749175772&partnerID=8YFLogxK
U2 - 10.1183/09031936.00140608
DO - 10.1183/09031936.00140608
M3 - Article
VL - 33
SP - 1003
EP - 1009
JO - European Respiratory Journal, Supplement
JF - European Respiratory Journal, Supplement
SN - 0903-1936
IS - 5
ER -