Jatropha natural products as potential therapeutic leads

Taotao Ling, Victor Hadi, Armand Guiguemde, Scott Landfear, Fatima Rivas

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Natural products (NPs) are nature's evolutionarily product, containing complex and diverse molecular structures. For the past two decades, pharmaceutical companies have focused on developing targeted therapeutic agents by screening libraries of small synthetic molecules. However, recent development of new technologies that improve the extraction/characterization process as well as new synthetic methodologies that render NP derivatization possible have ignited a revival in the field of NPs. NPs are now being used as a rich repository for drug discovery. Here we review recent work on the bioactive NPs derived from Jatropha isabelli along with their corresponding derivatives. Most of these NPs are sesquiterpenoids with unique molecular architectures. They display activity against various disease models and therefore may offer early compound leads for drug discovery programs.

Original languageEnglish (US)
Title of host publicationThe Formation, Structure and Activity of Phytochemicals
PublisherSpringer International Publishing
Pages77-98
Number of pages22
Volume45
ISBN (Print)9783319203973, 9783319203966
DOIs
StatePublished - Oct 14 2015

Fingerprint

Jatropha
Biological Products
drugs
therapeutics
disease models
derivatization
Drug Discovery
drug
chemical structure
sesquiterpenoids
Therapeutics
chemical derivatives
Small Molecule Libraries
screening
Lead compounds
Molecular Structure
Molecular structure
product
repository
Screening

Keywords

  • 1,4-Michael addition reaction
  • Anticancer
  • Antioxidant
  • Antiviral
  • Chikungunya virus (CHIKV)
  • Diterpene
  • Euphorbia
  • Glutathione (GSH)
  • Gram-positive bacterium
  • High throughput screening
  • Infectious agents
  • Jatropha
  • Jatrophone
  • Leishmania
  • Lignans
  • Macrocycles
  • Malaria
  • Mammalian cell
  • Mitochondria
  • Mukaiyama aldol reaction
  • Multidrug resistance (MDR)
  • Natural products
  • Nucleophilic
  • Oxidation
  • Parasite
  • Plant extracts
  • Plasmodium falciparum
  • Sesquiterpene
  • Vector

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Environmental Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ling, T., Hadi, V., Guiguemde, A., Landfear, S., & Rivas, F. (2015). Jatropha natural products as potential therapeutic leads. In The Formation, Structure and Activity of Phytochemicals (Vol. 45, pp. 77-98). Springer International Publishing. https://doi.org/10.1007/978-3-319-20397-3_3

Jatropha natural products as potential therapeutic leads. / Ling, Taotao; Hadi, Victor; Guiguemde, Armand; Landfear, Scott; Rivas, Fatima.

The Formation, Structure and Activity of Phytochemicals. Vol. 45 Springer International Publishing, 2015. p. 77-98.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ling, T, Hadi, V, Guiguemde, A, Landfear, S & Rivas, F 2015, Jatropha natural products as potential therapeutic leads. in The Formation, Structure and Activity of Phytochemicals. vol. 45, Springer International Publishing, pp. 77-98. https://doi.org/10.1007/978-3-319-20397-3_3
Ling T, Hadi V, Guiguemde A, Landfear S, Rivas F. Jatropha natural products as potential therapeutic leads. In The Formation, Structure and Activity of Phytochemicals. Vol. 45. Springer International Publishing. 2015. p. 77-98 https://doi.org/10.1007/978-3-319-20397-3_3
Ling, Taotao ; Hadi, Victor ; Guiguemde, Armand ; Landfear, Scott ; Rivas, Fatima. / Jatropha natural products as potential therapeutic leads. The Formation, Structure and Activity of Phytochemicals. Vol. 45 Springer International Publishing, 2015. pp. 77-98
@inbook{328e2d7e30d14ba3a37c1fb2fb914fa0,
title = "Jatropha natural products as potential therapeutic leads",
abstract = "Natural products (NPs) are nature's evolutionarily product, containing complex and diverse molecular structures. For the past two decades, pharmaceutical companies have focused on developing targeted therapeutic agents by screening libraries of small synthetic molecules. However, recent development of new technologies that improve the extraction/characterization process as well as new synthetic methodologies that render NP derivatization possible have ignited a revival in the field of NPs. NPs are now being used as a rich repository for drug discovery. Here we review recent work on the bioactive NPs derived from Jatropha isabelli along with their corresponding derivatives. Most of these NPs are sesquiterpenoids with unique molecular architectures. They display activity against various disease models and therefore may offer early compound leads for drug discovery programs.",
keywords = "1,4-Michael addition reaction, Anticancer, Antioxidant, Antiviral, Chikungunya virus (CHIKV), Diterpene, Euphorbia, Glutathione (GSH), Gram-positive bacterium, High throughput screening, Infectious agents, Jatropha, Jatrophone, Leishmania, Lignans, Macrocycles, Malaria, Mammalian cell, Mitochondria, Mukaiyama aldol reaction, Multidrug resistance (MDR), Natural products, Nucleophilic, Oxidation, Parasite, Plant extracts, Plasmodium falciparum, Sesquiterpene, Vector",
author = "Taotao Ling and Victor Hadi and Armand Guiguemde and Scott Landfear and Fatima Rivas",
year = "2015",
month = "10",
day = "14",
doi = "10.1007/978-3-319-20397-3_3",
language = "English (US)",
isbn = "9783319203973",
volume = "45",
pages = "77--98",
booktitle = "The Formation, Structure and Activity of Phytochemicals",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Jatropha natural products as potential therapeutic leads

AU - Ling, Taotao

AU - Hadi, Victor

AU - Guiguemde, Armand

AU - Landfear, Scott

AU - Rivas, Fatima

PY - 2015/10/14

Y1 - 2015/10/14

N2 - Natural products (NPs) are nature's evolutionarily product, containing complex and diverse molecular structures. For the past two decades, pharmaceutical companies have focused on developing targeted therapeutic agents by screening libraries of small synthetic molecules. However, recent development of new technologies that improve the extraction/characterization process as well as new synthetic methodologies that render NP derivatization possible have ignited a revival in the field of NPs. NPs are now being used as a rich repository for drug discovery. Here we review recent work on the bioactive NPs derived from Jatropha isabelli along with their corresponding derivatives. Most of these NPs are sesquiterpenoids with unique molecular architectures. They display activity against various disease models and therefore may offer early compound leads for drug discovery programs.

AB - Natural products (NPs) are nature's evolutionarily product, containing complex and diverse molecular structures. For the past two decades, pharmaceutical companies have focused on developing targeted therapeutic agents by screening libraries of small synthetic molecules. However, recent development of new technologies that improve the extraction/characterization process as well as new synthetic methodologies that render NP derivatization possible have ignited a revival in the field of NPs. NPs are now being used as a rich repository for drug discovery. Here we review recent work on the bioactive NPs derived from Jatropha isabelli along with their corresponding derivatives. Most of these NPs are sesquiterpenoids with unique molecular architectures. They display activity against various disease models and therefore may offer early compound leads for drug discovery programs.

KW - 1,4-Michael addition reaction

KW - Anticancer

KW - Antioxidant

KW - Antiviral

KW - Chikungunya virus (CHIKV)

KW - Diterpene

KW - Euphorbia

KW - Glutathione (GSH)

KW - Gram-positive bacterium

KW - High throughput screening

KW - Infectious agents

KW - Jatropha

KW - Jatrophone

KW - Leishmania

KW - Lignans

KW - Macrocycles

KW - Malaria

KW - Mammalian cell

KW - Mitochondria

KW - Mukaiyama aldol reaction

KW - Multidrug resistance (MDR)

KW - Natural products

KW - Nucleophilic

KW - Oxidation

KW - Parasite

KW - Plant extracts

KW - Plasmodium falciparum

KW - Sesquiterpene

KW - Vector

UR - http://www.scopus.com/inward/record.url?scp=84955690298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955690298&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-20397-3_3

DO - 10.1007/978-3-319-20397-3_3

M3 - Chapter

AN - SCOPUS:84955690298

SN - 9783319203973

SN - 9783319203966

VL - 45

SP - 77

EP - 98

BT - The Formation, Structure and Activity of Phytochemicals

PB - Springer International Publishing

ER -