Jatropha natural products as potential therapeutic leads

Taotao Ling, Victor Hadi, Armand Guiguemde, Scott Landfear, Fatima Rivas

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Natural products (NPs) are nature's evolutionarily product, containing complex and diverse molecular structures. For the past two decades, pharmaceutical companies have focused on developing targeted therapeutic agents by screening libraries of small synthetic molecules. However, recent development of new technologies that improve the extraction/characterization process as well as new synthetic methodologies that render NP derivatization possible have ignited a revival in the field of NPs. NPs are now being used as a rich repository for drug discovery. Here we review recent work on the bioactive NPs derived from Jatropha isabelli along with their corresponding derivatives. Most of these NPs are sesquiterpenoids with unique molecular architectures. They display activity against various disease models and therefore may offer early compound leads for drug discovery programs.

Original languageEnglish (US)
Title of host publicationThe Formation, Structure and Activity of Phytochemicals
PublisherSpringer International Publishing
Pages77-98
Number of pages22
Volume45
ISBN (Print)9783319203973, 9783319203966
DOIs
StatePublished - Oct 14 2015

Keywords

  • 1,4-Michael addition reaction
  • Anticancer
  • Antioxidant
  • Antiviral
  • Chikungunya virus (CHIKV)
  • Diterpene
  • Euphorbia
  • Glutathione (GSH)
  • Gram-positive bacterium
  • High throughput screening
  • Infectious agents
  • Jatropha
  • Jatrophone
  • Leishmania
  • Lignans
  • Macrocycles
  • Malaria
  • Mammalian cell
  • Mitochondria
  • Mukaiyama aldol reaction
  • Multidrug resistance (MDR)
  • Natural products
  • Nucleophilic
  • Oxidation
  • Parasite
  • Plant extracts
  • Plasmodium falciparum
  • Sesquiterpene
  • Vector

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Environmental Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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