Iterative image reconstruction algorithms in coronary CT angiography improve the detection of lipid-core plaque – a comparison with histology

Stefan B. Puchner, Maros Ferencik, Pal Maurovich-Horvat, Masataka Nakano, Fumiyuki Otsuka, Hans Ulrich Kauczor, Renu Virmani, Udo Hoffmann, Christopher L. Schlett

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objectives: To evaluate whether iterative reconstruction algorithms improve the diagnostic accuracy of coronary CT angiography (CCTA) for detection of lipid-core plaque (LCP) compared to histology.

Methods and materials: CCTA and histological data were acquired from three ex vivo hearts. CCTA images were reconstructed using filtered back projection (FBP), adaptive-statistical (ASIR) and model-based (MBIR) iterative algorithms. Vessel cross-sections were co-registered between FBP/ASIR/MBIR and histology. Plaque area

Results: Overall, 173 CCTA triplets (FBP/ASIR/MBIR) were co-registered with histology. LCP was present in 26 cross-sections. Average measured plaque area 2: 5.78 ± 2.29 vs. 3.39 ± 1.68 FBP; 5.92 ± 1.87 vs. 3.43 ± 1.62 ASIR; 6.40 ± 1.55 vs. 3.49 ± 1.50 MBIR; all p <0.0001). AUC for detecting LCP was 0.803/0.850/0.903 for FBP/ASIR/MBIR and was significantly higher for MBIR compared to FBP (p = 0.01). MBIR increased sensitivity for detection of LCP by CCTA.

Conclusion: Plaque area

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalEuropean Radiology
Volume25
Issue number1
DOIs
StatePublished - Nov 29 2014
Externally publishedYes

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Computer-Assisted Image Processing
Coronary Angiography
Histology
Lipids
Statistical Models
Area Under Curve
Computed Tomography Angiography

Keywords

  • Coronary CT angiography
  • Diagnostic accuracy
  • Iterative reconstruction algorithm
  • Low attenuation plaque
  • Vulnerable plaque

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Iterative image reconstruction algorithms in coronary CT angiography improve the detection of lipid-core plaque – a comparison with histology. / Puchner, Stefan B.; Ferencik, Maros; Maurovich-Horvat, Pal; Nakano, Masataka; Otsuka, Fumiyuki; Kauczor, Hans Ulrich; Virmani, Renu; Hoffmann, Udo; Schlett, Christopher L.

In: European Radiology, Vol. 25, No. 1, 29.11.2014, p. 15-23.

Research output: Contribution to journalArticle

Puchner, SB, Ferencik, M, Maurovich-Horvat, P, Nakano, M, Otsuka, F, Kauczor, HU, Virmani, R, Hoffmann, U & Schlett, CL 2014, 'Iterative image reconstruction algorithms in coronary CT angiography improve the detection of lipid-core plaque – a comparison with histology', European Radiology, vol. 25, no. 1, pp. 15-23. https://doi.org/10.1007/s00330-014-3404-6
Puchner, Stefan B. ; Ferencik, Maros ; Maurovich-Horvat, Pal ; Nakano, Masataka ; Otsuka, Fumiyuki ; Kauczor, Hans Ulrich ; Virmani, Renu ; Hoffmann, Udo ; Schlett, Christopher L. / Iterative image reconstruction algorithms in coronary CT angiography improve the detection of lipid-core plaque – a comparison with histology. In: European Radiology. 2014 ; Vol. 25, No. 1. pp. 15-23.
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