It still hurts: Altered endogenous opioid activity in the brain during social rejection and acceptance in major depressive disorder

D. T. Hsu, B. J. Sanford, K. K. Meyers, T. M. Love, K. E. Hazlett, Sara Walker, B. J. Mickey, R. A. Koeppe, S. A. Langenecker, J. K. Zubieta

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The μ-opioid receptor (MOR) system, well known for dampening physical pain, is also hypothesized to dampen 'social pain.' We used positron emission tomography scanning with the selective MOR radioligand [11C]carfentanil to test the hypothesis that MOR system activation (reflecting endogenous opioid release) in response to social rejection and acceptance is altered in medication-free patients diagnosed with current major depressive disorder (MDD, n = 17) compared with healthy controls (HCs, n = 18). During rejection, MDD patients showed reduced endogenous opioid release in brain regions regulating stress, mood and motivation, and slower emotional recovery compared with HCs. During acceptance, only HCs showed increased social motivation, which was positively correlated with endogenous opioid release in the nucleus accumbens, a reward structure. Altered endogenous opioid activity in MDD may hinder emotional recovery from negative social interactions and decrease pleasure derived from positive interactions. Both effects may reinforce depression, trigger relapse and contribute to poor treatment outcomes.

Original languageEnglish (US)
Pages (from-to)193-200
Number of pages8
JournalMolecular Psychiatry
Volume20
Issue number2
DOIs
StatePublished - Feb 1 2015

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Social Distance
Major Depressive Disorder
Opioid Analgesics
carfentanil
Brain
Motivation
Pain
Pleasure
Nucleus Accumbens
Opioid Receptors
Interpersonal Relations
Reward
Positron-Emission Tomography
Depression
Recurrence

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Hsu, D. T., Sanford, B. J., Meyers, K. K., Love, T. M., Hazlett, K. E., Walker, S., ... Zubieta, J. K. (2015). It still hurts: Altered endogenous opioid activity in the brain during social rejection and acceptance in major depressive disorder. Molecular Psychiatry, 20(2), 193-200. https://doi.org/10.1038/mp.2014.185

It still hurts : Altered endogenous opioid activity in the brain during social rejection and acceptance in major depressive disorder. / Hsu, D. T.; Sanford, B. J.; Meyers, K. K.; Love, T. M.; Hazlett, K. E.; Walker, Sara; Mickey, B. J.; Koeppe, R. A.; Langenecker, S. A.; Zubieta, J. K.

In: Molecular Psychiatry, Vol. 20, No. 2, 01.02.2015, p. 193-200.

Research output: Contribution to journalArticle

Hsu, DT, Sanford, BJ, Meyers, KK, Love, TM, Hazlett, KE, Walker, S, Mickey, BJ, Koeppe, RA, Langenecker, SA & Zubieta, JK 2015, 'It still hurts: Altered endogenous opioid activity in the brain during social rejection and acceptance in major depressive disorder', Molecular Psychiatry, vol. 20, no. 2, pp. 193-200. https://doi.org/10.1038/mp.2014.185
Hsu, D. T. ; Sanford, B. J. ; Meyers, K. K. ; Love, T. M. ; Hazlett, K. E. ; Walker, Sara ; Mickey, B. J. ; Koeppe, R. A. ; Langenecker, S. A. ; Zubieta, J. K. / It still hurts : Altered endogenous opioid activity in the brain during social rejection and acceptance in major depressive disorder. In: Molecular Psychiatry. 2015 ; Vol. 20, No. 2. pp. 193-200.
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