Issues, indications, and controversies regarding intratympanic steroid perfusion

Mohamed Hamid, Dennis Trune

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations


Purpose of Review: Office-based intratympanic inner ear steroid perfusion (ITPs) treatment for Ménières disease, autoimmune inner ear disease, and sudden sensorineural hearing loss has been expanding over the past 10ĝ€"15 years, yet remains controversial. The purpose of this review is to examine the current literature of basic science and human studies of ITPs treatment. Recent Findings: Animal studies exist regarding the delivery, distribution, biochemical, and microbiological changes in the inner ear post ITPs. However, few clinical studies exist on ITPs treatment in sudden sensorineural hearing loss and even less in treating Ménières disease. There are no consistent studies regarding drug delivery methods, type, and concentration of steroids. Moreover, there are no studies comparing ITPs results to the natural history of Ménières disease. Summary: ITPs has impacted otology and neurotology practice due to increased utilization. A sound understanding of the basic science and clinical studies is needed to establish long-term efficacy of ITPs in controlling hearing loss in Ménières disease by comparison to its natural history, as well as, potential application to other disorders.

Original languageEnglish (US)
Pages (from-to)434-440
Number of pages7
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Issue number5
StatePublished - Oct 2008


  • Dexamethasone perfusion
  • Intratympanic perfusion
  • Me nieres disease
  • sudden sensorineural hearing loss

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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