Abstract
Purpose of Review: Office-based intratympanic inner ear steroid perfusion (ITPs) treatment for Ménières disease, autoimmune inner ear disease, and sudden sensorineural hearing loss has been expanding over the past 10ĝ€"15 years, yet remains controversial. The purpose of this review is to examine the current literature of basic science and human studies of ITPs treatment. Recent Findings: Animal studies exist regarding the delivery, distribution, biochemical, and microbiological changes in the inner ear post ITPs. However, few clinical studies exist on ITPs treatment in sudden sensorineural hearing loss and even less in treating Ménières disease. There are no consistent studies regarding drug delivery methods, type, and concentration of steroids. Moreover, there are no studies comparing ITPs results to the natural history of Ménières disease. Summary: ITPs has impacted otology and neurotology practice due to increased utilization. A sound understanding of the basic science and clinical studies is needed to establish long-term efficacy of ITPs in controlling hearing loss in Ménières disease by comparison to its natural history, as well as, potential application to other disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 434-440 |
| Number of pages | 7 |
| Journal | Current Opinion in Otolaryngology and Head and Neck Surgery |
| Volume | 16 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 2008 |
Keywords
- Dexamethasone perfusion
- Intratympanic perfusion
- Me nieres disease
- sudden sensorineural hearing loss
ASJC Scopus subject areas
- Surgery
- Otorhinolaryngology