Isoproterenol inhibits the increase in microvascular membrane permeability produced by Bradykinin

Richard Mullins, Mark A. Malias, Russell W. Hudgens

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Bradykinin (BRADY) is hypothesized to cause the “capillary leak” syndrome in patients with sepsis, trauma, and burns. Our purpose was to determine if isoproterenol (ISO) reversed a BRADY-produced accelerated loss of intravascular fluid and protein into the interstitium of skin. An increase in microvascular permeability in canine hind paw skin was sustained by a continuous femoral artery infusion of BRADY (0.2 μg/kg/min). After 2 hours of BRADY, skin lymph flow (LYM FLOW μl/min) increased nine-fold and skin lymph-to-plasma total protein concentration ratio (RTP) was substantially increased. Mean blood flow in the femoral arteries was increased four-fold by the BRADY infusion. After 2 hours of BRADY-induced increased permeability, five of the ten dogs were started on intravenous ISO(2 μg/min continuously) which increased heart rate from 182 ± 15 to 222 ±11 beats/min. ISO reversed the increase in RTP produced by the BRADY. After 8 hours of BRADY, there was less tissue albumin in the dogs given ISO (14.5 ± 2.0 vs. 29.5 ± 6.6 mg/gram dry wgt, p <0.05 unpaired t-test). ISO can reverse the sustained increase in skin microvascular permeability produced by BRADY.

Original languageEnglish (US)
Pages (from-to)1053-1064
Number of pages12
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume29
Issue number8
StatePublished - 1989
Externally publishedYes

Fingerprint

Capillary Permeability
Bradykinin
Isoproterenol
Membranes
Skin
Lymph
Femoral Artery
Capillary Leak Syndrome
Dogs
Burns
Canidae
Blood Proteins
Albumins
Permeability
Sepsis
Heart Rate
Wounds and Injuries

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Surgery

Cite this

Isoproterenol inhibits the increase in microvascular membrane permeability produced by Bradykinin. / Mullins, Richard; Malias, Mark A.; Hudgens, Russell W.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 29, No. 8, 1989, p. 1053-1064.

Research output: Contribution to journalArticle

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