Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases

Kathleen S. Montine, Joseph Quinn, Jing Zhang, Joshua P. Fessel, L. Jackson Roberts, Jason D. Morrow, Thomas J. Montine

Research output: Contribution to journalArticle

187 Citations (Scopus)

Abstract

Lipid peroxidation is a major outcome of free radical-mediated injury to brain, where it directly damages membranes and generates a number of oxidized products. Some of the chemically and metabolically stable oxidation products are useful in vivo biomarkers of lipid peroxidation. These include the isoprostanes (IsoPs) and isofurans (IsoFs), derived from arachidonic acid (AA), and neuroprostanes (NeuroPs), derived from docosahexaenoic acid (DHA). We have shown increased levels of IsoPs, NeuroPs, and IsoFs in diseased regions of brain from patients who died from advanced Alzheimer's disease (AD) or Parkinson's disease (PD). Increased cerebrospinal fluid (CSF) levels of IsoPs are present in patients with AD or Huntington's disease (HD) early in the course of their illness, and CSF IsoPs may improve the laboratory diagnostic accuracy for AD. In contrast, quantification of IsoPs in plasma and urine of AD patients has yielded inconsistent results. These results indicate that brain lipid peroxidation is a potential therapeutic target early in the course of AD and HD, that CSF IsoPs may aid in the assessment of anti-oxidant experimental therapeutics and laboratory diagnosis of AD.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalChemistry and Physics of Lipids
Volume128
Issue number1-2
DOIs
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Neurodegenerative diseases
Isoprostanes
Neurodegenerative Diseases
Lipid Peroxidation
Alzheimer Disease
Lipids
Neuroprostanes
Cerebrospinal fluid
Cerebrospinal Fluid
Huntington Disease
Brain
Docosahexaenoic Acids
Clinical Laboratory Techniques
Brain Diseases
Arachidonic Acid
Oxidants
Brain Injuries
Free Radicals
Parkinson Disease
Biomarkers

Keywords

  • Alzheimer
  • Huntington
  • Isofurans
  • Isoprostanes
  • Neuroprostanes
  • Parkinson

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this

Montine, K. S., Quinn, J., Zhang, J., Fessel, J. P., Roberts, L. J., Morrow, J. D., & Montine, T. J. (2004). Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. Chemistry and Physics of Lipids, 128(1-2), 117-124. https://doi.org/10.1016/j.chemphyslip.2003.10.010

Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. / Montine, Kathleen S.; Quinn, Joseph; Zhang, Jing; Fessel, Joshua P.; Roberts, L. Jackson; Morrow, Jason D.; Montine, Thomas J.

In: Chemistry and Physics of Lipids, Vol. 128, No. 1-2, 03.2004, p. 117-124.

Research output: Contribution to journalArticle

Montine, KS, Quinn, J, Zhang, J, Fessel, JP, Roberts, LJ, Morrow, JD & Montine, TJ 2004, 'Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases', Chemistry and Physics of Lipids, vol. 128, no. 1-2, pp. 117-124. https://doi.org/10.1016/j.chemphyslip.2003.10.010
Montine, Kathleen S. ; Quinn, Joseph ; Zhang, Jing ; Fessel, Joshua P. ; Roberts, L. Jackson ; Morrow, Jason D. ; Montine, Thomas J. / Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. In: Chemistry and Physics of Lipids. 2004 ; Vol. 128, No. 1-2. pp. 117-124.
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