Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5

Pei Wen Chiang, Eric Fogel, Cynthia L. Jackson, Kim Lieuallen, Greg Lennon, Xuan Qu, Su Qing Wang, David M. Kurnit

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

We isolated the human homologue, SUPT5H, of the yeast transcription factor, SPT5. The human homologue is 1088 aa long compared to 1063 aa for the yeast gene. SUPT5H maps to 19q13, near the ryanodine receptor. Like its family member, SUPT6H, and like yeast SPT5, SUPT5H has a very acidic 5' domain. Like its family member, SUPT6H, but unlike yeast SPT5 or SPT6, SUPT5H has seven MAP kinase sites at its 5' end. In addition, SUPT5H lacks the novel 6-amino-acid repeat (consensus is S-T/A-W-G-G-A/Q) at the C-terminus of yeast SPT5. This argues that while there is functional similarity between SPT5 and SUPT5H, the molecules differ in the signals to which they respond.

Original languageEnglish (US)
Pages (from-to)421-424
Number of pages4
JournalGenomics
Volume38
Issue number3
DOIs
StatePublished - Dec 15 1996

ASJC Scopus subject areas

  • Genetics

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    Chiang, P. W., Fogel, E., Jackson, C. L., Lieuallen, K., Lennon, G., Qu, X., Wang, S. Q., & Kurnit, D. M. (1996). Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5. Genomics, 38(3), 421-424. https://doi.org/10.1006/geno.1996.0646