Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5

Pei Wen Chiang; Eric Fogel; Cynthia L. Jackson; Kim Lieuallen; Greg Lennon; Xuan Qu; Su Qing Wang; David M. Kurnit

doi:10.1006/geno.1996.0646

Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5

Pei Wen Chiang, Eric Fogel, Cynthia L. Jackson, Kim Lieuallen, Greg Lennon, Xuan Qu, Su Qing Wang, David M. Kurnit

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We isolated the human homologue, SUPT5H, of the yeast transcription factor, SPT5. The human homologue is 1088 aa long compared to 1063 aa for the yeast gene. SUPT5H maps to 19q13, near the ryanodine receptor. Like its family member, SUPT6H, and like yeast SPT5, SUPT5H has a very acidic 5' domain. Like its family member, SUPT6H, but unlike yeast SPT5 or SPT6, SUPT5H has seven MAP kinase sites at its 5' end. In addition, SUPT5H lacks the novel 6-amino-acid repeat (consensus is S-T/A-W-G-G-A/Q) at the C-terminus of yeast SPT5. This argues that while there is functional similarity between SPT5 and SUPT5H, the molecules differ in the signals to which they respond.

Original language	English (US)
Pages (from-to)	421-424
Number of pages	4
Journal	Genomics
Volume	38
Issue number	3
DOIs	https://doi.org/10.1006/geno.1996.0646
State	Published - Dec 15 1996
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1006/geno.1996.0646

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title = "Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5",

abstract = "We isolated the human homologue, SUPT5H, of the yeast transcription factor, SPT5. The human homologue is 1088 aa long compared to 1063 aa for the yeast gene. SUPT5H maps to 19q13, near the ryanodine receptor. Like its family member, SUPT6H, and like yeast SPT5, SUPT5H has a very acidic 5' domain. Like its family member, SUPT6H, but unlike yeast SPT5 or SPT6, SUPT5H has seven MAP kinase sites at its 5' end. In addition, SUPT5H lacks the novel 6-amino-acid repeat (consensus is S-T/A-W-G-G-A/Q) at the C-terminus of yeast SPT5. This argues that while there is functional similarity between SPT5 and SUPT5H, the molecules differ in the signals to which they respond.",

author = "Chiang, {Pei Wen} and Eric Fogel and Jackson, {Cynthia L.} and Kim Lieuallen and Greg Lennon and Xuan Qu and Wang, {Su Qing} and Kurnit, {David M.}",

note = "Funding Information: We thank K. Walsh and R. M. Preparata for technical assistance. Support was from NIH Grant 1 R01 HG00923, DOE Grant DE-FG02-91ER61136, and by the Howard Hughes Medical Institute. D.M.K. is an Investigator at the Howard Hughes Medical Institute. Work by G.L. and K.L. was supported by DOE Contract W-7405-Eng-48.",

year = "1996",

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doi = "10.1006/geno.1996.0646",

language = "English (US)",

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AU - Chiang, Pei Wen

AU - Fogel, Eric

AU - Jackson, Cynthia L.

AU - Lieuallen, Kim

AU - Lennon, Greg

AU - Qu, Xuan

AU - Wang, Su Qing

AU - Kurnit, David M.

N1 - Funding Information: We thank K. Walsh and R. M. Preparata for technical assistance. Support was from NIH Grant 1 R01 HG00923, DOE Grant DE-FG02-91ER61136, and by the Howard Hughes Medical Institute. D.M.K. is an Investigator at the Howard Hughes Medical Institute. Work by G.L. and K.L. was supported by DOE Contract W-7405-Eng-48.

PY - 1996/12/15

Y1 - 1996/12/15

N2 - We isolated the human homologue, SUPT5H, of the yeast transcription factor, SPT5. The human homologue is 1088 aa long compared to 1063 aa for the yeast gene. SUPT5H maps to 19q13, near the ryanodine receptor. Like its family member, SUPT6H, and like yeast SPT5, SUPT5H has a very acidic 5' domain. Like its family member, SUPT6H, but unlike yeast SPT5 or SPT6, SUPT5H has seven MAP kinase sites at its 5' end. In addition, SUPT5H lacks the novel 6-amino-acid repeat (consensus is S-T/A-W-G-G-A/Q) at the C-terminus of yeast SPT5. This argues that while there is functional similarity between SPT5 and SUPT5H, the molecules differ in the signals to which they respond.

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Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5

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