Isolation rearing-induced deficits in contextual fear learning do not require CRF2 receptors

Jodi E. Gresack, Victoria B. Risbrough, Christine N. Scott, Sarah Coste, Mary Stenzel-Poore, Mark A. Geyer, Susan B. Powell

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Post-weaning social isolation of rodents is used to model developmental stressors linked to neuropsychiatric disorders including schizophrenia as well as anxiety and mood disorders. Isolation rearing produces alterations in emotional memory and hippocampal neuropathology. Corticotropin releasing factor (CRF) signaling has recently been shown to be involved in behavioral effects of isolation rearing. Activation of the CRF2 receptor is linked to stress-induced alterations in fear learning and may also be involved in long-term adaptation to stress. Here we tested the hypothesis that CRF2 contributes to isolation rearing effects on emotional memory. At weaning, mice were housed either in groups of three or individually in standard mouse cages. In adulthood, isolation-reared mice exhibited significant reductions in context-specific, but not cue-specific, freezing. Isolation-reared mice exhibited no significant changes in locomotor exploration during brief exposure to a novel environment, suggesting that the reduced freezing in response to context cues was not due to activity confounds. Isolation rearing also disrupted context fear memory in mice with a CRF2 gene null mutation, indicating that the CRF2 receptor is not required for isolation effects on fear memory. Thus, isolation rearing disrupts hippocampal-dependent fear learning as indicated by consistent reductions in context-conditioned freezing in two separate cohorts of mice, and these effects are via a CRF2-independent mechanism. These findings may be clinically relevant because they suggest that isolation rearing in mice may be a useful model of developmental perturbations linked to disruptions in emotional memory in a variety of neuropsychiatric disorders.

Original languageEnglish (US)
Pages (from-to)80-84
Number of pages5
JournalBehavioural Brain Research
Volume209
Issue number1
DOIs
StatePublished - May 1 2010

Fingerprint

Fear
Learning
Freezing
Weaning
Cues
Cohort Effect
Social Isolation
Corticotropin-Releasing Hormone
CRF receptor type 2
Anxiety Disorders
Mood Disorders
Rodentia
Schizophrenia
Mutation
Genes

Keywords

  • Corticotropin releasing factor
  • Emotional memory
  • Fear conditioning
  • Locomotor activity
  • Mice
  • Social isolation

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Isolation rearing-induced deficits in contextual fear learning do not require CRF2 receptors. / Gresack, Jodi E.; Risbrough, Victoria B.; Scott, Christine N.; Coste, Sarah; Stenzel-Poore, Mary; Geyer, Mark A.; Powell, Susan B.

In: Behavioural Brain Research, Vol. 209, No. 1, 01.05.2010, p. 80-84.

Research output: Contribution to journalArticle

Gresack, Jodi E. ; Risbrough, Victoria B. ; Scott, Christine N. ; Coste, Sarah ; Stenzel-Poore, Mary ; Geyer, Mark A. ; Powell, Susan B. / Isolation rearing-induced deficits in contextual fear learning do not require CRF2 receptors. In: Behavioural Brain Research. 2010 ; Vol. 209, No. 1. pp. 80-84.
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