Isolation of a second nonallelic insulin-like growth factor I gene from the salmon genome

V. M. Kavsan, V. A. Grebenjuk, A. P. Koval, A. S. Skorokhod, Charles Roberts, D. LeRoith

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We have characterized a second nonallelic insulin-like growth factor-I (IGF-I) gene in the chum salmon (Oncorhynchus keta) genome. This gene, IGF- I.2, differs from the previously described chum salmon IGF-I gene, IGF-I.1, in the E peptide-coding portion of exon 3; specifically, the IGF-I.2 gene lacks one codon present in the IGF-I gene and contains two potential splice donor sites at the 3' end of exon 3 rather than the single, more distal site present in the IGF-I.1 gene. The expression of these two IGF-I genes could give rise to as many as six IGF-I mRNA species, each of which would encode a unique E-peptide moiety of the IGF-I pro-hormone. Thus, the presence of multiple, distinct IGF genes adds an additional level of complexity to IGF-I gene expression and IGF-I biosynthesis in salmon.

Original languageEnglish (US)
Pages (from-to)555-559
Number of pages5
JournalDNA and Cell Biology
Volume13
Issue number5
StatePublished - 1994
Externally publishedYes

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Salmon
Insulin-Like Growth Factor I
Genome
Oncorhynchus keta
Genes
Exons
RNA Splice Sites
Tocopherols
Codon
Hormones
Gene Expression
Messenger RNA
Peptides

ASJC Scopus subject areas

  • Cell Biology
  • Genetics
  • Molecular Biology

Cite this

Kavsan, V. M., Grebenjuk, V. A., Koval, A. P., Skorokhod, A. S., Roberts, C., & LeRoith, D. (1994). Isolation of a second nonallelic insulin-like growth factor I gene from the salmon genome. DNA and Cell Biology, 13(5), 555-559.

Isolation of a second nonallelic insulin-like growth factor I gene from the salmon genome. / Kavsan, V. M.; Grebenjuk, V. A.; Koval, A. P.; Skorokhod, A. S.; Roberts, Charles; LeRoith, D.

In: DNA and Cell Biology, Vol. 13, No. 5, 1994, p. 555-559.

Research output: Contribution to journalArticle

Kavsan, VM, Grebenjuk, VA, Koval, AP, Skorokhod, AS, Roberts, C & LeRoith, D 1994, 'Isolation of a second nonallelic insulin-like growth factor I gene from the salmon genome', DNA and Cell Biology, vol. 13, no. 5, pp. 555-559.
Kavsan VM, Grebenjuk VA, Koval AP, Skorokhod AS, Roberts C, LeRoith D. Isolation of a second nonallelic insulin-like growth factor I gene from the salmon genome. DNA and Cell Biology. 1994;13(5):555-559.
Kavsan, V. M. ; Grebenjuk, V. A. ; Koval, A. P. ; Skorokhod, A. S. ; Roberts, Charles ; LeRoith, D. / Isolation of a second nonallelic insulin-like growth factor I gene from the salmon genome. In: DNA and Cell Biology. 1994 ; Vol. 13, No. 5. pp. 555-559.
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