Isolation of a Second Nonallelic Insulin-Like Growth Factor I Gene from the Salmon Genome

Vadim M. Kavsan, Vladislav A. Grebenjuk, Anatoly P. Koval, Alexander S. Skorokhod, Charles T. Roberts, Derek Leroith

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

We have characterized a second nonallelic insulin-like growth factor-I (IGF-I) gene in the chum salmon (Oncorhynchus keta) genome. This gene, IGF-I.2, differs from the previously described chum salmon IGF-I gene, IGF-I.1, in the E peptide-coding portion of exon 3; specifically, the IGF-I.2 gene lacks one codon present in the IGF-I gene and contains two potential splice donor sites at the 3′ end of exon 3 rather than the single, more distal site present in the IGF-I.1 gene. The expression of these two IGF-I genes could give rise to as many as six IGF-I mRN A species, each of which would encode a unique E-peptide moiety of the IGF-I prohormone. Thus, the presence of multiple, distinct IGF genes adds an additional level of complexity to IGF-I gene expression and IGF-I biosynthesis in salmon.

Original languageEnglish (US)
Pages (from-to)555-559
Number of pages5
JournalDNA and Cell Biology
Volume13
Issue number5
DOIs
StatePublished - May 1994
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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