Isoforms of the Na,K-ATPase are present in both axons and dendrites of hippocampal neurons in culture

G. Pietrini, M. Matteoli, G. Banker, M. J. Caplan

Research output: Contribution to journalArticlepeer-review

132 Scopus citations

Abstract

The distributions of isoforms of the Na,K-ATPase α subunit were determined in mature cultured hippocampal neurons and in a polarized epithelial cell line. We find that hippocampal neurons express the α1 and α3 isoforms in the membranes of both axons and dendrites. In contrast the α1 and α3 proteins are exclusively basolateral when expressed endogenously or by stable transfection in renal epithelial cells. These data suggest that epithelial cells and hippocampal neurons localize these proteins by different mechanisms. These observations contrast with those made for the vesicular stomatitis virus and the influenza glycoproteins, which are polarized in both epithelial and neuronal cells.

Original languageEnglish (US)
Pages (from-to)8414-8418
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number18
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • General

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