Isoform-dependent effects of apoE on doublecortin-positive cells and microtubule-associated protein 2 immunoreactivity following 137Cs irradiation

Laura Villasana, Timothy Pfankuch, Jacob Raber

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Previously we found apoE isoform-dependent effects of 137Cs irradiation on cognitive function of female mice 3 months following irradiation. Alterations in the number of immature neurons and in the levels of the dendritic marker microtubule-associated protein 2 (MAP-2) might contribute to the cognitive changes following irradiation. Therefore, in the present study we determined if, following 137Cs irradiation, there are apoE isoform-dependent effects on loss of doublecortin-positive neuroprogenitor cells or MAP-2 immumonoreactivity. In the dentate gyrus, CA1 and CA3 regions of the hippocampus, enthorhinal and sensorimotor cortex, and central and basolateral nuclei of the amygdala of apoE3 female mice, MAP-2 immunoreactivity increased 3 months following 137Cs irradiation. In addition, at 8 h following irradiation, the number of doublecortin-positive cells was higher in apoE3 than apoE2 or apoE4 mice. Together, these data indicate that brains of apoE3 mice respond differently to 137Cs irradiation than those of apoE2 or apoE4 mice.

Original languageEnglish (US)
Pages (from-to)421-426
Number of pages6
JournalRadiation and Environmental Biophysics
Volume49
Issue number3
DOIs
StatePublished - Aug 1 2010

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Environmental Science(all)

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