Isoflurane differentially modulates inhibitory and excitatory synaptic transmission to the solitary tract nucleus

James H. Peters, Stuart J. McDougall, David Mendelowitz, Dennis Koop, Michael Andresen

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

BACKGROUND: Isoflurane anesthesia produces cardiovascular and respiratory depression, although the specific mechanisms are not fully understood. Cranial visceral afferents, which innervate the heart and lungs, synapse centrally onto neurons within the medial portion of the nucleus tractus solitarius (NTS). Isoflurane modulation of afferent to NTS synaptic communication may underlie compromised cardiorespiratory reflex function. METHODS: Adult rat hindbrain slice preparations containing the solitary tract (ST) and NTS were used. Shocks to ST afferents evoked excitatory postsynaptic currents with low-variability (SEM

Original languageEnglish (US)
Pages (from-to)675-683
Number of pages9
JournalAnesthesiology
Volume108
Issue number4
DOIs
StatePublished - Apr 2008

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Solitary Nucleus
Isoflurane
Synaptic Transmission
Visceral Afferents
Rhombencephalon
Excitatory Postsynaptic Potentials
Respiratory Insufficiency
Synapses
Reflex
Shock
Anesthesia
Communication
Neurons
Lung

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Isoflurane differentially modulates inhibitory and excitatory synaptic transmission to the solitary tract nucleus. / Peters, James H.; McDougall, Stuart J.; Mendelowitz, David; Koop, Dennis; Andresen, Michael.

In: Anesthesiology, Vol. 108, No. 4, 04.2008, p. 675-683.

Research output: Contribution to journalArticle

Peters, James H. ; McDougall, Stuart J. ; Mendelowitz, David ; Koop, Dennis ; Andresen, Michael. / Isoflurane differentially modulates inhibitory and excitatory synaptic transmission to the solitary tract nucleus. In: Anesthesiology. 2008 ; Vol. 108, No. 4. pp. 675-683.
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