Abstract
In the present review, the role of lipid disturbances is evaluated as a risk factor in the pathogenesis and the potential acceleration of atherosclerosis in uremic patients undergoing long-term hemodialysis. The alteration in high density lipoprotein composition with a decrease in high density lipoprotein cholesterol but a normal apoprotein AI content may have relevance to the atherogenetic process. Moreover, the accumulation of cholesterol-rich, very low density lipoproteins and intermediate density lipoproteins may play a major role in atherosclerosis since these degradation products of triglyceride-rich particles are considered as atherogenic. The hypothesis should be tested whether a correction of the abnormal catabolism of triglyceride-rich lipoproteins in uremic patients leads to a decrease in ischemic vascular events.
Original language | English (US) |
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Pages (from-to) | 42-51 |
Number of pages | 10 |
Journal | Blood Purification |
Volume | 3 |
Issue number | 1-3 |
DOIs | |
State | Published - 1985 |
Externally published | Yes |
Keywords
- Atherosclerosis
- Hemodialysis patients
- Lipids
- Lipoprotein anomalies
- Uremia
ASJC Scopus subject areas
- Hematology
- Nephrology