Is there a treatment necessity for lipid disorders of uremic patients?

Bernard Lacour, Jean Baptiste Roullet, Pascale Beyne, Tilman Drüeke

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In the present review, the role of lipid disturbances is evaluated as a risk factor in the pathogenesis and the potential acceleration of atherosclerosis in uremic patients undergoing long-term hemodialysis. The alteration in high density lipoprotein composition with a decrease in high density lipoprotein cholesterol but a normal apoprotein AI content may have relevance to the atherogenetic process. Moreover, the accumulation of cholesterol-rich, very low density lipoproteins and intermediate density lipoproteins may play a major role in atherosclerosis since these degradation products of triglyceride-rich particles are considered as atherogenic. The hypothesis should be tested whether a correction of the abnormal catabolism of triglyceride-rich lipoproteins in uremic patients leads to a decrease in ischemic vascular events.

Original languageEnglish (US)
Pages (from-to)42-51
Number of pages10
JournalBlood Purification
Volume3
Issue number1-3
DOIs
StatePublished - Jan 1 1985

Keywords

  • Atherosclerosis
  • Hemodialysis patients
  • Lipids
  • Lipoprotein anomalies
  • Uremia

ASJC Scopus subject areas

  • Hematology
  • Nephrology

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