Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?

Milena K. Pavlova, Steven Shea, Frank A J L Scheer, Edward B. Bromfield

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Epileptiform abnormalities often occur at specific times of day or night, possibly attributable to state of consciousness (sleep vs. wake) and/or influences from the endogenous circadian pacemaker. In this pilot study we tested for the existence of circadian variation of interictal epileptiform discharges (IEDs), independent of changes in state, environment, or behavior. Five patients with generalized epilepsy underwent a protocol whereby their sleep/wake schedule was evenly distributed across the circadian cycle while undergoing full-montage electroencephalography and hourly plasma melatonin measurements. Light was

Original languageEnglish (US)
Pages (from-to)461-467
Number of pages7
JournalEpilepsy and Behavior
Volume16
Issue number3
DOIs
StatePublished - Nov 2009
Externally publishedYes

Fingerprint

Sleep
Generalized Epilepsy
Melatonin
Consciousness
Electroencephalography
Appointments and Schedules
Light
Idiopathic Generalized Epilepsy

Keywords

  • Circadian
  • Epilepsy
  • Idiopathic generalized epilepsy
  • Interictal discharges
  • Nocturnal
  • Sleep
  • Sleep/wake distribution

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this

Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy? / Pavlova, Milena K.; Shea, Steven; Scheer, Frank A J L; Bromfield, Edward B.

In: Epilepsy and Behavior, Vol. 16, No. 3, 11.2009, p. 461-467.

Research output: Contribution to journalArticle

Pavlova, Milena K. ; Shea, Steven ; Scheer, Frank A J L ; Bromfield, Edward B. / Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?. In: Epilepsy and Behavior. 2009 ; Vol. 16, No. 3. pp. 461-467.
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