Is newer safer? Adverse events associated with first-line therapies for ANCA-associated vasculitis and lupus nephritis

Jonathan Hogan, Rupali Avasare, Jai Radhakrishnan

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Clinical outcomes in ANCA-associated vasculitis (AAV) and lupus nephritis have improved greatly with treatment regimens containing high-dose glucocorticoids and cyclophosphamide. However, with the use of these medications come significant adverse events,most notably infections, cytopenias,malignancies, and reproductive abnormalities. Multiple recent randomized controlled trials in AAV and lupus nephritis have compared cyclophosphamide-based regimenswith agents such as rituximab, mycophenolate mofetil, and azathioprine, with the hope of providing better clinical outcomes with improved safety profiles. Although some of these newer regimens are now considered first-line treatments of these diseases, their adverse event profiles have been disappointingly similar to those of cyclophosphamide-based protocols. Physicians and patients should consider the adverse event profiles generated by these trials in the context of their extensive use in other patient populations, aswell as available measures to prevent such events, when choosing the ideal regimen for an individual patient.

Original languageEnglish (US)
Pages (from-to)1657-1667
Number of pages11
JournalClinical Journal of the American Society of Nephrology
Volume9
Issue number9
DOIs
StatePublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

Fingerprint Dive into the research topics of 'Is newer safer? Adverse events associated with first-line therapies for ANCA-associated vasculitis and lupus nephritis'. Together they form a unique fingerprint.

Cite this