Is multiple sclerosis a mitochondrial disease?

Peizhong Mao, P. Hemachandra Reddy

Research output: Contribution to journalReview articlepeer-review

155 Scopus citations

Abstract

Multiple sclerosis (MS) is a relatively common and etiologically unknown disease with no cure. It is the leading cause of neurological disability in young adults, affecting over two million people worldwide. Traditionally, MS has been considered a chronic, inflammatory disorder of the central white matter in which ensuing demyelination results in physical disability. Recently, MS has become increasingly viewed as a neurodegenerative disorder in which axonal injury, neuronal loss, and atrophy of the central nervous system leads to permanent neurological and clinical disability. In this article, we discuss the latest developments on MS research, including etiology, pathology, genetic association, EAE animal models, mechanisms of neuronal injury and axonal transport, and therapeutics. In this article, we also focus on the mechanisms of mitochondrial dysfunction that are involved in MS, including mitochondrial DNA defects, and mitochondrial structural/functional changes.

Original languageEnglish (US)
Pages (from-to)66-79
Number of pages14
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1802
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Keywords

  • Experimental autoimmune encephalomyelitis
  • Gender difference
  • Mitochondria
  • Multiple sclerosis
  • Myelin
  • NO
  • Neuroprotection
  • Oxidative stress

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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