Is isolated low high-density lipoprotein cholesterol a cardiovascular disease risk factor?

Jacquelaine Bartlett, Irene M. Predazzi, Scott M. Williams, William S. Bush, Yeunjung Kim, Stephen Havas, Peter P. Toth, Sergio Fazio, Michael Miller

    Research output: Contribution to journalArticle

    37 Scopus citations

    Abstract

    Background - Although the inverse association between high-density lipoprotein cholesterol (HDL-C) and risk of cardiovascular disease (CVD) has been long established, it remains unclear whether low HDL-C remains a CVD risk factor when levels of low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) are not elevated. This is a timely issue because recent studies have questioned whether HDL-C is truly an independent predictor of CVD. Methods and Results - 3590 men and women from the Framingham Heart Study offspring cohort without known CVD were followed between 1987 and 2011. Low HDL-C (

    Original languageEnglish (US)
    Pages (from-to)206-212
    Number of pages7
    JournalCirculation: Cardiovascular Quality and Outcomes
    Volume9
    Issue number3
    DOIs
    StatePublished - May 1 2016

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    Keywords

    • coronary heart disease risk
    • epidemiology
    • high-density lipoprotein cholesterol
    • low-density lipoprotein cholesterol
    • triglycerides

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Cite this

    Bartlett, J., Predazzi, I. M., Williams, S. M., Bush, W. S., Kim, Y., Havas, S., Toth, P. P., Fazio, S., & Miller, M. (2016). Is isolated low high-density lipoprotein cholesterol a cardiovascular disease risk factor? Circulation: Cardiovascular Quality and Outcomes, 9(3), 206-212. https://doi.org/10.1161/CIRCOUTCOMES.115.002436