Is isolated low high-density lipoprotein cholesterol a cardiovascular disease risk factor?

Jacquelaine Bartlett, Irene M. Predazzi, Scott M. Williams, William S. Bush, Yeunjung Kim, Stephen Havas, Peter P. Toth, Sergio Fazio, Michael Miller

    Research output: Contribution to journalArticle

    32 Citations (Scopus)

    Abstract

    Background - Although the inverse association between high-density lipoprotein cholesterol (HDL-C) and risk of cardiovascular disease (CVD) has been long established, it remains unclear whether low HDL-C remains a CVD risk factor when levels of low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) are not elevated. This is a timely issue because recent studies have questioned whether HDL-C is truly an independent predictor of CVD. Methods and Results - 3590 men and women from the Framingham Heart Study offspring cohort without known CVD were followed between 1987 and 2011. Low HDL-C (

    Original languageEnglish (US)
    Pages (from-to)206-212
    Number of pages7
    JournalCirculation: Cardiovascular Quality and Outcomes
    Volume9
    Issue number3
    DOIs
    StatePublished - May 1 2016

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    LDL Cholesterol
    HDL Cholesterol
    Cardiovascular Diseases
    Cohort Studies

    Keywords

    • coronary heart disease risk
    • epidemiology
    • high-density lipoprotein cholesterol
    • low-density lipoprotein cholesterol
    • triglycerides

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Cite this

    Is isolated low high-density lipoprotein cholesterol a cardiovascular disease risk factor? / Bartlett, Jacquelaine; Predazzi, Irene M.; Williams, Scott M.; Bush, William S.; Kim, Yeunjung; Havas, Stephen; Toth, Peter P.; Fazio, Sergio; Miller, Michael.

    In: Circulation: Cardiovascular Quality and Outcomes, Vol. 9, No. 3, 01.05.2016, p. 206-212.

    Research output: Contribution to journalArticle

    Bartlett, J, Predazzi, IM, Williams, SM, Bush, WS, Kim, Y, Havas, S, Toth, PP, Fazio, S & Miller, M 2016, 'Is isolated low high-density lipoprotein cholesterol a cardiovascular disease risk factor?', Circulation: Cardiovascular Quality and Outcomes, vol. 9, no. 3, pp. 206-212. https://doi.org/10.1161/CIRCOUTCOMES.115.002436
    Bartlett, Jacquelaine ; Predazzi, Irene M. ; Williams, Scott M. ; Bush, William S. ; Kim, Yeunjung ; Havas, Stephen ; Toth, Peter P. ; Fazio, Sergio ; Miller, Michael. / Is isolated low high-density lipoprotein cholesterol a cardiovascular disease risk factor?. In: Circulation: Cardiovascular Quality and Outcomes. 2016 ; Vol. 9, No. 3. pp. 206-212.
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    AU - Havas, Stephen

    AU - Toth, Peter P.

    AU - Fazio, Sergio

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