Is food allergy testing reliable in pediatric atopic dermatitis? A population-based study

Laura E. Keck, Eric Simpson, Trista M. Berry, Jon Hanifin

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

We sought to assess the value and reliability of serologic testing for predicting clinical food allergy in a population-based cohort of infants with atopic dermatitis (AD). Infants 3-18 months of age, recruited from the general population, were followed quarterly for 3 years and carefully evaluated for evidence of immediate reactions to foods. Specific serum IgE levels for six foods were assayed at 3-5 years. Parents were interviewed at each visit regarding past/current immediate food-specific reactions involving skin, gut or respiratory systems. Data were entered into Excel for calculations of performance characteristics. Nine of the 40 patients (23%) who completed 3 years of follow-up had reactions to one or more foods. Reactions occurred in 5, 11 and 18% to milk, peanut and egg ingestion, respectively. In contrast, 30% of food-specific serum IgE tests were above normal. Predictive reliability of tests was generally low unless values were in the high range for peanut and milk. Conversely, egg allergy could be seen across a nearly full-spectrum of IgE values, making prediction highly unreliable. We conclude that physician and patient misinterpretation of the relevance and reliability of allergy testing may misdirect proper prevention and therapy of AD.

Original languageEnglish (US)
Title of host publicationChemical Immunology and Allergy
Pages108-112
Number of pages5
Volume96
DOIs
StatePublished - Mar 2012

Publication series

NameChemical Immunology and Allergy
Volume96
ISSN (Print)16602242
ISSN (Electronic)16622898

Fingerprint

Food Hypersensitivity
Atopic Dermatitis
Pediatrics
Food
Immunoglobulin E
Population
Milk
Egg Hypersensitivity
Serum
Respiratory System
Ovum
Hypersensitivity
Eating
Parents
Physicians
Skin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Keck, L. E., Simpson, E., Berry, T. M., & Hanifin, J. (2012). Is food allergy testing reliable in pediatric atopic dermatitis? A population-based study. In Chemical Immunology and Allergy (Vol. 96, pp. 108-112). (Chemical Immunology and Allergy; Vol. 96). https://doi.org/10.1159/000331906

Is food allergy testing reliable in pediatric atopic dermatitis? A population-based study. / Keck, Laura E.; Simpson, Eric; Berry, Trista M.; Hanifin, Jon.

Chemical Immunology and Allergy. Vol. 96 2012. p. 108-112 (Chemical Immunology and Allergy; Vol. 96).

Research output: Chapter in Book/Report/Conference proceedingChapter

Keck, LE, Simpson, E, Berry, TM & Hanifin, J 2012, Is food allergy testing reliable in pediatric atopic dermatitis? A population-based study. in Chemical Immunology and Allergy. vol. 96, Chemical Immunology and Allergy, vol. 96, pp. 108-112. https://doi.org/10.1159/000331906
Keck LE, Simpson E, Berry TM, Hanifin J. Is food allergy testing reliable in pediatric atopic dermatitis? A population-based study. In Chemical Immunology and Allergy. Vol. 96. 2012. p. 108-112. (Chemical Immunology and Allergy). https://doi.org/10.1159/000331906
Keck, Laura E. ; Simpson, Eric ; Berry, Trista M. ; Hanifin, Jon. / Is food allergy testing reliable in pediatric atopic dermatitis? A population-based study. Chemical Immunology and Allergy. Vol. 96 2012. pp. 108-112 (Chemical Immunology and Allergy).
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