Is Biopsy Gleason Score Independently Associated With Biochemical Progression Following Radical Prostatectomy After Adjusting for Pathological Gleason Score?

Nicholas J. Fitzsimons, Joseph C. Presti, Christopher J. Kane, Martha K. Terris, William J. Aronson, Christopher Amling, Stephen J. Freedland

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Purpose: Biopsy Gleason score is known to be associated with prostate specific antigen failure following radical prostatectomy. However, it is unclear whether it remains associated with outcome after surgery when the pathological Gleason score is known. Materials and Methods: We determined the association between biopsy Gleason score and biochemical progression after correcting for preoperative and postoperative characteristics, including pathological Gleason score, in 1,931 men treated with radical prostatectomy between 1988 and 2005 in the Shared Equal Access Regional Cancer Hospital Database Study Group database. Gleason score was examined as a categorical variable of 2 to 6, 3 + 4 and 4 + 3 or greater. Results: Higher biopsy Gleason scores were positively associated with extracapsular extension (p

Original languageEnglish (US)
Pages (from-to)2453-2458
Number of pages6
JournalJournal of Urology
Volume176
Issue number6
DOIs
StatePublished - Dec 2006
Externally publishedYes

Fingerprint

Neoplasm Grading
Prostatectomy
Biopsy
Databases
Cancer Care Facilities
Prostate-Specific Antigen

Keywords

  • biopsy
  • disease progression
  • prostate
  • prostatectomy
  • prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Is Biopsy Gleason Score Independently Associated With Biochemical Progression Following Radical Prostatectomy After Adjusting for Pathological Gleason Score? / Fitzsimons, Nicholas J.; Presti, Joseph C.; Kane, Christopher J.; Terris, Martha K.; Aronson, William J.; Amling, Christopher; Freedland, Stephen J.

In: Journal of Urology, Vol. 176, No. 6, 12.2006, p. 2453-2458.

Research output: Contribution to journalArticle

Fitzsimons, Nicholas J. ; Presti, Joseph C. ; Kane, Christopher J. ; Terris, Martha K. ; Aronson, William J. ; Amling, Christopher ; Freedland, Stephen J. / Is Biopsy Gleason Score Independently Associated With Biochemical Progression Following Radical Prostatectomy After Adjusting for Pathological Gleason Score?. In: Journal of Urology. 2006 ; Vol. 176, No. 6. pp. 2453-2458.
@article{8776c94318194077b6cf61f98e56c1e7,
title = "Is Biopsy Gleason Score Independently Associated With Biochemical Progression Following Radical Prostatectomy After Adjusting for Pathological Gleason Score?",
abstract = "Purpose: Biopsy Gleason score is known to be associated with prostate specific antigen failure following radical prostatectomy. However, it is unclear whether it remains associated with outcome after surgery when the pathological Gleason score is known. Materials and Methods: We determined the association between biopsy Gleason score and biochemical progression after correcting for preoperative and postoperative characteristics, including pathological Gleason score, in 1,931 men treated with radical prostatectomy between 1988 and 2005 in the Shared Equal Access Regional Cancer Hospital Database Study Group database. Gleason score was examined as a categorical variable of 2 to 6, 3 + 4 and 4 + 3 or greater. Results: Higher biopsy Gleason scores were positively associated with extracapsular extension (p",
keywords = "biopsy, disease progression, prostate, prostatectomy, prostatic neoplasms",
author = "Fitzsimons, {Nicholas J.} and Presti, {Joseph C.} and Kane, {Christopher J.} and Terris, {Martha K.} and Aronson, {William J.} and Christopher Amling and Freedland, {Stephen J.}",
year = "2006",
month = "12",
doi = "10.1016/j.juro.2006.08.014",
language = "English (US)",
volume = "176",
pages = "2453--2458",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Is Biopsy Gleason Score Independently Associated With Biochemical Progression Following Radical Prostatectomy After Adjusting for Pathological Gleason Score?

AU - Fitzsimons, Nicholas J.

AU - Presti, Joseph C.

AU - Kane, Christopher J.

AU - Terris, Martha K.

AU - Aronson, William J.

AU - Amling, Christopher

AU - Freedland, Stephen J.

PY - 2006/12

Y1 - 2006/12

N2 - Purpose: Biopsy Gleason score is known to be associated with prostate specific antigen failure following radical prostatectomy. However, it is unclear whether it remains associated with outcome after surgery when the pathological Gleason score is known. Materials and Methods: We determined the association between biopsy Gleason score and biochemical progression after correcting for preoperative and postoperative characteristics, including pathological Gleason score, in 1,931 men treated with radical prostatectomy between 1988 and 2005 in the Shared Equal Access Regional Cancer Hospital Database Study Group database. Gleason score was examined as a categorical variable of 2 to 6, 3 + 4 and 4 + 3 or greater. Results: Higher biopsy Gleason scores were positively associated with extracapsular extension (p

AB - Purpose: Biopsy Gleason score is known to be associated with prostate specific antigen failure following radical prostatectomy. However, it is unclear whether it remains associated with outcome after surgery when the pathological Gleason score is known. Materials and Methods: We determined the association between biopsy Gleason score and biochemical progression after correcting for preoperative and postoperative characteristics, including pathological Gleason score, in 1,931 men treated with radical prostatectomy between 1988 and 2005 in the Shared Equal Access Regional Cancer Hospital Database Study Group database. Gleason score was examined as a categorical variable of 2 to 6, 3 + 4 and 4 + 3 or greater. Results: Higher biopsy Gleason scores were positively associated with extracapsular extension (p

KW - biopsy

KW - disease progression

KW - prostate

KW - prostatectomy

KW - prostatic neoplasms

UR - http://www.scopus.com/inward/record.url?scp=33751070801&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751070801&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2006.08.014

DO - 10.1016/j.juro.2006.08.014

M3 - Article

C2 - 17085127

AN - SCOPUS:33751070801

VL - 176

SP - 2453

EP - 2458

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 6

ER -