Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal

Ramesh Kandimalla, Vani Thirumala, P. Hemachandra Reddy

    Research output: Contribution to journalReview articlepeer-review

    175 Scopus citations

    Abstract

    Recently researchers proposed the term ‘Type-3-Diabetes’ for Alzheimer's disease (ad) because of the shared molecular and cellular features among Type-1-Diabetes, Type-2-Diabetes and insulin resistance associated with memory deficits and cognitive decline in elderly individuals. Recent clinical and basic studies on patients with diabetes and AD revealed previously unreported cellular and pathological among diabetes, insulin resistance and AD. These studies are also strengthened by various basic biological studies that decipher the effects of insulin in the pathology of AD through cellular and molecular mechanisms. For instance, insulin is involved in the activation of glycogen synthase kinase 3β, which in turn causes phosphorylation of tau, which involved in the formation of neurofibrillary tangles. Interestingly, insulin also plays a crucial role in the formation amyloid plaques. In this review, we discussed significant shared mechanisms between AD and diabetes and we also provided therapeutic avenues for diabetes and AD. This article is part of a Special Issue entitled: Oxidative Stress and Mitochondrial Quality in Diabetes/Obesity and Critical Illness Spectrum of Diseases - edited by P. Hemachandra Reddy.

    Original languageEnglish (US)
    Pages (from-to)1078-1089
    Number of pages12
    JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
    Volume1863
    Issue number5
    DOIs
    StatePublished - May 1 2017

    Keywords

    • Alzheimer's disease
    • BMI
    • GSK3β
    • MCI amyloid beta
    • Obesity
    • Tau
    • Type-3-Diabetes
    • diabetes

    ASJC Scopus subject areas

    • Molecular Medicine
    • Molecular Biology

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