TY - JOUR
T1 - IrvA-dependent and IrvA-independent pathways for mutacin gene regulation in Streptococcus mutans
AU - Tsang, Phoebe
AU - Merritt, Justin
AU - Shi, Wenyuan
AU - Qi, Fengxia
PY - 2006/8
Y1 - 2006/8
N2 - Streptococcus mutans is a primary pathogen associated with dental caries. Its bacteriocin (mutacin) production ability is thought to play an important role in maintaining competitiveness in the multispecies oral biofilm. Previous studies have demonstrated that the production of the lantibiotic, mutacin I, is responsive to multiple input signals and that a putative inducible repressor, irvA, seems to be involved in the luxS-mediated mutacin I gene regulation pathway. In this study, we demonstrate that these multiple inputs can be divided into two pathways: irvA-dependent and irvA-independent. Similar to luxS, signals mediated through vicK, pttB and hk03 exert their effect possibly through modulating irvA transcription, whereas signals mediated through ciaH, hrcA, adhE, and Smu1281 exert their effect through an unknown mechanism independent of irvA.
AB - Streptococcus mutans is a primary pathogen associated with dental caries. Its bacteriocin (mutacin) production ability is thought to play an important role in maintaining competitiveness in the multispecies oral biofilm. Previous studies have demonstrated that the production of the lantibiotic, mutacin I, is responsive to multiple input signals and that a putative inducible repressor, irvA, seems to be involved in the luxS-mediated mutacin I gene regulation pathway. In this study, we demonstrate that these multiple inputs can be divided into two pathways: irvA-dependent and irvA-independent. Similar to luxS, signals mediated through vicK, pttB and hk03 exert their effect possibly through modulating irvA transcription, whereas signals mediated through ciaH, hrcA, adhE, and Smu1281 exert their effect through an unknown mechanism independent of irvA.
KW - Bacteriocin
KW - Gene regulation
KW - Mutacin I
KW - Streptococcus mutans
KW - irvA
UR - http://www.scopus.com/inward/record.url?scp=33746579752&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746579752&partnerID=8YFLogxK
U2 - 10.1111/j.1574-6968.2006.00351.x
DO - 10.1111/j.1574-6968.2006.00351.x
M3 - Article
C2 - 16907725
AN - SCOPUS:33746579752
SN - 0378-1097
VL - 261
SP - 231
EP - 234
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
IS - 2
ER -