Irreversible inhibition of mammalian and insect peptidylglycine α-hydroxylating monooxygenases (PHMS), peptide amidating enzymes, by N-formyl amides

Michael Klinge, Hengmiao Cheng, T. Mark Zabriskie, John C. Vederas

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

A series of N-formyl amides were synthesized by condensation of N,N-bis(trimethylsilyl)formamide with acid chlorides (59-90% yields), or by reaction of hydroxyglycyl peptides with 90% hydrogen peroxide (45% yield); a number of N-formyl amides which bear a phenyl substituent are mechanism-based irreversible inactivators of peptidylglycine α-hydroxylating monooxygenases purified from pig pituitary and from honeybee heads.

Original languageEnglish (US)
Pages (from-to)1379-1380
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number11
DOIs
StatePublished - Dec 1 1994

ASJC Scopus subject areas

  • Molecular Medicine

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