A series of N-formyl amides were synthesized by condensation of N,N-bis(trimethylsilyl)formamide with acid chlorides (59-90% yields), or by reaction of hydroxyglycyl peptides with 90% hydrogen peroxide (45% yield); a number of N-formyl amides which bear a phenyl substituent are mechanism-based irreversible inactivators of peptidylglycine α-hydroxylating monooxygenases purified from pig pituitary and from honeybee heads.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of the Chemical Society, Chemical Communications|
|State||Published - Dec 1 1994|
ASJC Scopus subject areas
- Molecular Medicine