Iron homeostasis and eye disease

Allison Loh, Majda Hadziahmetovic, Joshua L. Dunaief

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Background: Iron is necessary for life, but excess iron can be toxic to tissues. Iron is thought to damage tissues primarily by generating oxygen free radicals through the Fenton reaction. Methods: We present an overview of the evidence supporting iron's potential contribution to a broad range of eye disease using an anatomical approach. Results: Iron can be visualized in the cornea as iron lines in the normal aging cornea as well as in diseases like keratoconus and pterygium. In the lens, we present the evidence for the role of oxidative damage in cataractogenesis. Also, we review the evidence that iron may play a role in the pathogenesis of the retinal disease age-related macular degeneration. Although currently there is no direct link between excess iron and development of optic neuropathies, ferrous iron's ability to form highly reactive oxygen species may play a role in optic nerve pathology. Lastly, we discuss recent advances in prevention and therapeutics for eye disease with antioxidants and iron chelators. General significance: Iron homeostasis is important for ocular health.

Original languageEnglish (US)
Pages (from-to)637-649
Number of pages13
JournalBiochimica et Biophysica Acta - General Subjects
Volume1790
Issue number7
DOIs
StatePublished - Jul 2009
Externally publishedYes

Fingerprint

Eye Diseases
Homeostasis
Iron
Cornea
Reactive Oxygen Species
Optics
Tissue
Pterygium
Keratoconus
Retinal Diseases
Optic Nerve Diseases
Poisons
Macular Degeneration
Pathology
Chelating Agents
Optic Nerve
Lenses
Free Radicals
Antioxidants
Aging of materials

Keywords

  • Chelator
  • Cornea
  • Iron
  • Lens
  • Oxidative stress
  • Retina

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Iron homeostasis and eye disease. / Loh, Allison; Hadziahmetovic, Majda; Dunaief, Joshua L.

In: Biochimica et Biophysica Acta - General Subjects, Vol. 1790, No. 7, 07.2009, p. 637-649.

Research output: Contribution to journalArticle

Loh, Allison ; Hadziahmetovic, Majda ; Dunaief, Joshua L. / Iron homeostasis and eye disease. In: Biochimica et Biophysica Acta - General Subjects. 2009 ; Vol. 1790, No. 7. pp. 637-649.
@article{9eadf494886a4ce999958464232f98c7,
title = "Iron homeostasis and eye disease",
abstract = "Background: Iron is necessary for life, but excess iron can be toxic to tissues. Iron is thought to damage tissues primarily by generating oxygen free radicals through the Fenton reaction. Methods: We present an overview of the evidence supporting iron's potential contribution to a broad range of eye disease using an anatomical approach. Results: Iron can be visualized in the cornea as iron lines in the normal aging cornea as well as in diseases like keratoconus and pterygium. In the lens, we present the evidence for the role of oxidative damage in cataractogenesis. Also, we review the evidence that iron may play a role in the pathogenesis of the retinal disease age-related macular degeneration. Although currently there is no direct link between excess iron and development of optic neuropathies, ferrous iron's ability to form highly reactive oxygen species may play a role in optic nerve pathology. Lastly, we discuss recent advances in prevention and therapeutics for eye disease with antioxidants and iron chelators. General significance: Iron homeostasis is important for ocular health.",
keywords = "Chelator, Cornea, Iron, Lens, Oxidative stress, Retina",
author = "Allison Loh and Majda Hadziahmetovic and Dunaief, {Joshua L.}",
year = "2009",
month = "7",
doi = "10.1016/j.bbagen.2008.11.001",
language = "English (US)",
volume = "1790",
pages = "637--649",
journal = "Biochimica et Biophysica Acta - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",
number = "7",

}

TY - JOUR

T1 - Iron homeostasis and eye disease

AU - Loh, Allison

AU - Hadziahmetovic, Majda

AU - Dunaief, Joshua L.

PY - 2009/7

Y1 - 2009/7

N2 - Background: Iron is necessary for life, but excess iron can be toxic to tissues. Iron is thought to damage tissues primarily by generating oxygen free radicals through the Fenton reaction. Methods: We present an overview of the evidence supporting iron's potential contribution to a broad range of eye disease using an anatomical approach. Results: Iron can be visualized in the cornea as iron lines in the normal aging cornea as well as in diseases like keratoconus and pterygium. In the lens, we present the evidence for the role of oxidative damage in cataractogenesis. Also, we review the evidence that iron may play a role in the pathogenesis of the retinal disease age-related macular degeneration. Although currently there is no direct link between excess iron and development of optic neuropathies, ferrous iron's ability to form highly reactive oxygen species may play a role in optic nerve pathology. Lastly, we discuss recent advances in prevention and therapeutics for eye disease with antioxidants and iron chelators. General significance: Iron homeostasis is important for ocular health.

AB - Background: Iron is necessary for life, but excess iron can be toxic to tissues. Iron is thought to damage tissues primarily by generating oxygen free radicals through the Fenton reaction. Methods: We present an overview of the evidence supporting iron's potential contribution to a broad range of eye disease using an anatomical approach. Results: Iron can be visualized in the cornea as iron lines in the normal aging cornea as well as in diseases like keratoconus and pterygium. In the lens, we present the evidence for the role of oxidative damage in cataractogenesis. Also, we review the evidence that iron may play a role in the pathogenesis of the retinal disease age-related macular degeneration. Although currently there is no direct link between excess iron and development of optic neuropathies, ferrous iron's ability to form highly reactive oxygen species may play a role in optic nerve pathology. Lastly, we discuss recent advances in prevention and therapeutics for eye disease with antioxidants and iron chelators. General significance: Iron homeostasis is important for ocular health.

KW - Chelator

KW - Cornea

KW - Iron

KW - Lens

KW - Oxidative stress

KW - Retina

UR - http://www.scopus.com/inward/record.url?scp=67349135968&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349135968&partnerID=8YFLogxK

U2 - 10.1016/j.bbagen.2008.11.001

DO - 10.1016/j.bbagen.2008.11.001

M3 - Article

C2 - 19059309

AN - SCOPUS:67349135968

VL - 1790

SP - 637

EP - 649

JO - Biochimica et Biophysica Acta - General Subjects

JF - Biochimica et Biophysica Acta - General Subjects

SN - 0304-4165

IS - 7

ER -