Irinotecan and paclitaxel in metastatic adenocarcinoma of the esophagus and gastric cardia.

J. Randolph Hecht; Charles D. Blanke; A. B. Benson; Heinz J. Lenz

Irinotecan and paclitaxel in metastatic adenocarcinoma of the esophagus and gastric cardia.

J. Randolph Hecht, Charles D. Blanke, A. B. Benson, Heinz J. Lenz

Research output: Contribution to journal › Article › peer-review

Abstract

Both irinotecan (CPT-11, Camptosar) and paclitaxel have been shown to have single-agent activity in adenocarcinomas of the esophagus and gastric cardia. A phase I trial of the combination at UCLA established the dose as irinotecan at 225 mg/m2 and paclitaxel at 100 mg/m2 every 3 weeks. Preliminary data from a phase II trial of this regimen in adenocarcinomas of the gastroesophageal junction show good tolerability and promising activity (response rate of 27%), even in previously treated patients.

Original language	English (US)
Pages (from-to)	13-15
Number of pages	3
Journal	Oncology (Williston Park, N.Y.)
Volume	17
Issue number	9 Suppl 8
State	Published - 2003
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Irinotecan and paclitaxel in metastatic adenocarcinoma of the esophagus and gastric cardia.",

abstract = "Both irinotecan (CPT-11, Camptosar) and paclitaxel have been shown to have single-agent activity in adenocarcinomas of the esophagus and gastric cardia. A phase I trial of the combination at UCLA established the dose as irinotecan at 225 mg/m2 and paclitaxel at 100 mg/m2 every 3 weeks. Preliminary data from a phase II trial of this regimen in adenocarcinomas of the gastroesophageal junction show good tolerability and promising activity (response rate of 27%), even in previously treated patients.",

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AU - Blanke, Charles D.

AU - Benson, A. B.

AU - Lenz, Heinz J.

PY - 2003

Y1 - 2003

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AB - Both irinotecan (CPT-11, Camptosar) and paclitaxel have been shown to have single-agent activity in adenocarcinomas of the esophagus and gastric cardia. A phase I trial of the combination at UCLA established the dose as irinotecan at 225 mg/m2 and paclitaxel at 100 mg/m2 every 3 weeks. Preliminary data from a phase II trial of this regimen in adenocarcinomas of the gastroesophageal junction show good tolerability and promising activity (response rate of 27%), even in previously treated patients.

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JF - Oncology (Williston Park, N.Y.)

IS - 9 Suppl 8

ER -

Irinotecan and paclitaxel in metastatic adenocarcinoma of the esophagus and gastric cardia.

Abstract

ASJC Scopus subject areas

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