Ionized calcium and magnesium: The effect of septic shock in the baboon

Donald Trunkey, Mary Ann Carpenter, James Holcroft

    Research output: Contribution to journalArticle

    20 Scopus citations

    Abstract

    Ionized calcium (Ca2+) and ionized magnesium (Mg2+) are important intracellular “second messengers” and control excitation-contraction coupling, excitation-secretion, oxidative phosphorylation, and mitochondrial acid-base balance. The present study examines the effect of septic shock on serum (Ca2+) and (Mg2+). Five adult female baboons were subjected to live E. coli septic shock and then resuscitated. Three baboons served as controls. Ca2+ was measured by the Orion SS-20 flow-through calcium electrode and Mg2+ calculated by the method of Killen. Other measurements included: total calcium, bound calcium, total magnesium, bound magnesium, phosphate, albumin, globulin, hemotocrit, and total protein. This study shows that there are significant disturbances of Ca2+ and Mg2+ during septic shock in the baboon. These disturbances may in part explain cellular dysfunction during shock including: decreased myocardial contractility, inappropriate secretion of endocrine cells, decrease in oxidative phosphorylation, and mitochondrial acidosis.

    Original languageEnglish (US)
    Pages (from-to)166-172
    Number of pages7
    JournalJournal of Trauma - Injury, Infection and Critical Care
    Volume18
    Issue number3
    DOIs
    StatePublished - Mar 1978

    ASJC Scopus subject areas

    • Surgery
    • Critical Care and Intensive Care Medicine

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