TY - JOUR
T1 - Ionized calcium and magnesium
T2 - The effect of septic shock in the baboon
AU - Trunkey, Donald
AU - Carpenter, Mary Ann
AU - Holcroft, James
PY - 1978/3
Y1 - 1978/3
N2 - Ionized calcium (Ca2+) and ionized magnesium (Mg2+) are important intracellular “second messengers” and control excitation-contraction coupling, excitation-secretion, oxidative phosphorylation, and mitochondrial acid-base balance. The present study examines the effect of septic shock on serum (Ca2+) and (Mg2+). Five adult female baboons were subjected to live E. coli septic shock and then resuscitated. Three baboons served as controls. Ca2+ was measured by the Orion SS-20 flow-through calcium electrode and Mg2+ calculated by the method of Killen. Other measurements included: total calcium, bound calcium, total magnesium, bound magnesium, phosphate, albumin, globulin, hemotocrit, and total protein. This study shows that there are significant disturbances of Ca2+ and Mg2+ during septic shock in the baboon. These disturbances may in part explain cellular dysfunction during shock including: decreased myocardial contractility, inappropriate secretion of endocrine cells, decrease in oxidative phosphorylation, and mitochondrial acidosis.
AB - Ionized calcium (Ca2+) and ionized magnesium (Mg2+) are important intracellular “second messengers” and control excitation-contraction coupling, excitation-secretion, oxidative phosphorylation, and mitochondrial acid-base balance. The present study examines the effect of septic shock on serum (Ca2+) and (Mg2+). Five adult female baboons were subjected to live E. coli septic shock and then resuscitated. Three baboons served as controls. Ca2+ was measured by the Orion SS-20 flow-through calcium electrode and Mg2+ calculated by the method of Killen. Other measurements included: total calcium, bound calcium, total magnesium, bound magnesium, phosphate, albumin, globulin, hemotocrit, and total protein. This study shows that there are significant disturbances of Ca2+ and Mg2+ during septic shock in the baboon. These disturbances may in part explain cellular dysfunction during shock including: decreased myocardial contractility, inappropriate secretion of endocrine cells, decrease in oxidative phosphorylation, and mitochondrial acidosis.
UR - http://www.scopus.com/inward/record.url?scp=0018193534&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018193534&partnerID=8YFLogxK
U2 - 10.1097/00005373-197803000-00002
DO - 10.1097/00005373-197803000-00002
M3 - Article
C2 - 417190
AN - SCOPUS:0018193534
SN - 0022-5282
VL - 18
SP - 166
EP - 172
JO - Journal of Trauma - Injury, Infection and Critical Care
JF - Journal of Trauma - Injury, Infection and Critical Care
IS - 3
ER -