Ion homeostasis in the ear

Mechanisms, maladies, and management

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Purpose of Review To describe ion and water homeostatic mechanisms in the inner ear, how they are compromised in hearing disorders, and what treatments are employed to restore auditory function. Recent Findings: The ion and water transport functions in the inner ear help maintain the proper endolymph K + concentration required for hair cell function. Gene defects and idiopathic alterations in these transport functions cause hearing loss, but often the underlying cause is unknown. Current therapies largely involve glucocorticoid treatment, although the mechanisms of restoration are often undeterminable. Recent studies of these ion homeostatic functions in the ear are characterizing their cellular and molecular control. It is anticipated that future management of these hearing disorders will be more targeted to the cellular processes involved and improve the likelihood of hearing recovery. Summary: A better understanding of the ion homeostatic processes in the ear will permit more effective management of their associated hearing disorders. Sufficient insight into many homeostatic hearing disorders has now been attained to usher in a new era of better therapies and improved clinical outcomes.

Original languageEnglish (US)
Pages (from-to)413-419
Number of pages7
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Volume18
Issue number5
DOIs
StatePublished - Oct 2010

Fingerprint

Hearing Disorders
Ear
Homeostasis
Ions
Inner Ear
Endolymph
Water
Ion Transport
Therapeutics
Hearing Loss
Glucocorticoids
Hearing
Genes

Keywords

  • endolymph
  • hearing loss
  • inflammation
  • inner ear
  • ion homeostasis
  • Meniere's disease
  • middle ear

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

Ion homeostasis in the ear : Mechanisms, maladies, and management. / Trune, Dennis.

In: Current Opinion in Otolaryngology and Head and Neck Surgery, Vol. 18, No. 5, 10.2010, p. 413-419.

Research output: Contribution to journalArticle

@article{be1a3b9f71754740b6426425444dabc4,
title = "Ion homeostasis in the ear: Mechanisms, maladies, and management",
abstract = "Purpose of Review To describe ion and water homeostatic mechanisms in the inner ear, how they are compromised in hearing disorders, and what treatments are employed to restore auditory function. Recent Findings: The ion and water transport functions in the inner ear help maintain the proper endolymph K + concentration required for hair cell function. Gene defects and idiopathic alterations in these transport functions cause hearing loss, but often the underlying cause is unknown. Current therapies largely involve glucocorticoid treatment, although the mechanisms of restoration are often undeterminable. Recent studies of these ion homeostatic functions in the ear are characterizing their cellular and molecular control. It is anticipated that future management of these hearing disorders will be more targeted to the cellular processes involved and improve the likelihood of hearing recovery. Summary: A better understanding of the ion homeostatic processes in the ear will permit more effective management of their associated hearing disorders. Sufficient insight into many homeostatic hearing disorders has now been attained to usher in a new era of better therapies and improved clinical outcomes.",
keywords = "endolymph, hearing loss, inflammation, inner ear, ion homeostasis, Meniere's disease, middle ear",
author = "Dennis Trune",
year = "2010",
month = "10",
doi = "10.1097/MOO.0b013e32833d9597",
language = "English (US)",
volume = "18",
pages = "413--419",
journal = "Current Opinion in Otolaryngology and Head and Neck Surgery",
issn = "1068-9508",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Ion homeostasis in the ear

T2 - Mechanisms, maladies, and management

AU - Trune, Dennis

PY - 2010/10

Y1 - 2010/10

N2 - Purpose of Review To describe ion and water homeostatic mechanisms in the inner ear, how they are compromised in hearing disorders, and what treatments are employed to restore auditory function. Recent Findings: The ion and water transport functions in the inner ear help maintain the proper endolymph K + concentration required for hair cell function. Gene defects and idiopathic alterations in these transport functions cause hearing loss, but often the underlying cause is unknown. Current therapies largely involve glucocorticoid treatment, although the mechanisms of restoration are often undeterminable. Recent studies of these ion homeostatic functions in the ear are characterizing their cellular and molecular control. It is anticipated that future management of these hearing disorders will be more targeted to the cellular processes involved and improve the likelihood of hearing recovery. Summary: A better understanding of the ion homeostatic processes in the ear will permit more effective management of their associated hearing disorders. Sufficient insight into many homeostatic hearing disorders has now been attained to usher in a new era of better therapies and improved clinical outcomes.

AB - Purpose of Review To describe ion and water homeostatic mechanisms in the inner ear, how they are compromised in hearing disorders, and what treatments are employed to restore auditory function. Recent Findings: The ion and water transport functions in the inner ear help maintain the proper endolymph K + concentration required for hair cell function. Gene defects and idiopathic alterations in these transport functions cause hearing loss, but often the underlying cause is unknown. Current therapies largely involve glucocorticoid treatment, although the mechanisms of restoration are often undeterminable. Recent studies of these ion homeostatic functions in the ear are characterizing their cellular and molecular control. It is anticipated that future management of these hearing disorders will be more targeted to the cellular processes involved and improve the likelihood of hearing recovery. Summary: A better understanding of the ion homeostatic processes in the ear will permit more effective management of their associated hearing disorders. Sufficient insight into many homeostatic hearing disorders has now been attained to usher in a new era of better therapies and improved clinical outcomes.

KW - endolymph

KW - hearing loss

KW - inflammation

KW - inner ear

KW - ion homeostasis

KW - Meniere's disease

KW - middle ear

UR - http://www.scopus.com/inward/record.url?scp=77957785425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957785425&partnerID=8YFLogxK

U2 - 10.1097/MOO.0b013e32833d9597

DO - 10.1097/MOO.0b013e32833d9597

M3 - Article

VL - 18

SP - 413

EP - 419

JO - Current Opinion in Otolaryngology and Head and Neck Surgery

JF - Current Opinion in Otolaryngology and Head and Neck Surgery

SN - 1068-9508

IS - 5

ER -