Iodothyronamines are oxidatively deaminated to iodothyroacetic acids in vivo

Warren J.L. Wood, Travis Geraci, Aaron Nilsen, Andrea E. DeBarber, Thomas S. Scanlan

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

3-Iodothyronamine (T1AM) and 3,3′,5-triiodothyroacetic acid (Triac) are bioactive metabolites of the hormone thyroxine (T4). In the present study, the ability of T1AM and 3,3′,5-triiodothyronamine (T3AM) to be metabolized to 3-iodothyroacetic acid (TA1) and Triac, respectively, was investigated. Both T1AM and T3AM were converted to their respective iodinated thyroacetic acid analogues in both cell and tissue extracts. This conversion could be significantly inhibited with the monamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) inhibitor iproniazid. TA1 was found to be present in trace quantities in human serum and in substantial levels in serum from T1AM-treated rats. These results demonstrate that iodothyronamines are substrates for amine oxidases and that this metabolism may be the source of the corresponding endogenous arylacetic acid products Triac and TA1.

Original languageEnglish (US)
Pages (from-to)361-365
Number of pages5
JournalChemBioChem
Volume10
Issue number2
DOIs
StatePublished - Jan 26 2009

Keywords

  • Biosynthesis
  • Biotransformations
  • Iodothyroacetic acids
  • Iodothyronamines
  • Metabolism

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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