TY - JOUR
T1 - Iodine based radiopacity of experimental blood clots for testing of mechanical thrombectomy devices
AU - Luo, Zhong Hua
AU - Chung, Alex
AU - Choi, Gibok
AU - Lin, Yih Huie
AU - Pang, Huajin
AU - Uchida, Barry
AU - Pavcnik, Dusan
AU - Jeromel, Miran
AU - Keller, Frederick S.
AU - Rosch, Josef
N1 - Funding Information:
This study was partially supported by the Inje Research and Scholarship Foundation in 2011.
PY - 2013/3
Y1 - 2013/3
N2 - Background. Barium sulfate powder used for radiopacity of experimental blood clots (EBCs) for testing mechanical thrombectomy devices (MTD) has negative effects on EBCs mechanical properties. In vitro and in vivo exploration was performed to determine if the iodine based contrast medium will have less negative effects on the EBCs than barium. Materials and methods. Fresh blood from 2 swine was used to create fibrinogen enhanced and thrombin initiated EBC in tubes. Iodine radiopacity was achieved by mixing the blood with 65% Iohexol or by soaking the EBCs for 2 or 24 hours in Iohexol. The EBCs opacified with barium served as controls. In vitro study: The EBCs were subjected to four tests, manual elongation, catheter injection, radiopacity and contrast wash out tests. In vivo study: The common carotid arteries of 2 swine were embolized by either barium EBC or EBC soaked for 24 hours in Iohexol. The duration of radiopacity of the different EBCs was compared. Results. The EBCs opacified with Iohexol initially had higher radiopacity than the barium opacified EBCs. However, their opacity rapidly decreased with saline soaking and, particularly, after they were embolized in live animals. The mechanical properties of Iohexol opacified EBCs were inferior to barium opacified EBCs. The Iohexol mixed EBCs were less firm and elastic and half of them fragmented during catheter injection. The Iohexol soaked EBCs exhibited decreased tensile strength and elasticity compared to the barium EBCs. Conclusions. Compared to barium, iodine based contrast medium does not offer any advantage for opacifying EBCs.
AB - Background. Barium sulfate powder used for radiopacity of experimental blood clots (EBCs) for testing mechanical thrombectomy devices (MTD) has negative effects on EBCs mechanical properties. In vitro and in vivo exploration was performed to determine if the iodine based contrast medium will have less negative effects on the EBCs than barium. Materials and methods. Fresh blood from 2 swine was used to create fibrinogen enhanced and thrombin initiated EBC in tubes. Iodine radiopacity was achieved by mixing the blood with 65% Iohexol or by soaking the EBCs for 2 or 24 hours in Iohexol. The EBCs opacified with barium served as controls. In vitro study: The EBCs were subjected to four tests, manual elongation, catheter injection, radiopacity and contrast wash out tests. In vivo study: The common carotid arteries of 2 swine were embolized by either barium EBC or EBC soaked for 24 hours in Iohexol. The duration of radiopacity of the different EBCs was compared. Results. The EBCs opacified with Iohexol initially had higher radiopacity than the barium opacified EBCs. However, their opacity rapidly decreased with saline soaking and, particularly, after they were embolized in live animals. The mechanical properties of Iohexol opacified EBCs were inferior to barium opacified EBCs. The Iohexol mixed EBCs were less firm and elastic and half of them fragmented during catheter injection. The Iohexol soaked EBCs exhibited decreased tensile strength and elasticity compared to the barium EBCs. Conclusions. Compared to barium, iodine based contrast medium does not offer any advantage for opacifying EBCs.
KW - Animal model
KW - Experimental radiology
KW - Preclinical interventional radiology
KW - Radioopaque experimental clot
KW - Stroke
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U2 - 10.2478/raon-2013-0001
DO - 10.2478/raon-2013-0001
M3 - Article
C2 - 23450088
AN - SCOPUS:84877955336
VL - 47
SP - 14
EP - 18
JO - Radiology and Oncology
JF - Radiology and Oncology
SN - 1318-2099
IS - 1
ER -