Iodine-123 metaiodobenzylguanidine imaging of the heart in idiopathic congestive cardiomyopathy and cardiac transplants

J. V. Glowniak, F. E. Turner, L. L. Gray, R. T. Palac, M. C. Lagunas-Solar, William Woodward

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

Iodine-123 metaiodobenzylguanidine ([123I]MIBG) is a norepinephrine analog which can be used to image the sympathetic innervation of the heart. In this study, cardiac imaging with [123I]MIBG was performed in patients with idiopathic congestive cardiomyopathy and compared to normal controls. Initial uptake, half-time of tracer within the heart, and heart to lung ratios were all significantly reduced in patients compared to normals. Uptake in lungs, liver, salivary glands, and spleen was similar in controls and patients with cardiomyopathy indicating that decreased MIBG uptake was not a generalized abnormality in these patients. Iodine-123 MIBG imaging was also performed in cardiac transplant patients to determine cardiac nonneuronal uptake. Uptake in transplants was

Original languageEnglish (US)
Pages (from-to)1182-1191
Number of pages10
JournalJournal of Nuclear Medicine
Volume30
Issue number7
StatePublished - 1989
Externally publishedYes

Fingerprint

3-Iodobenzylguanidine
Dilated Cardiomyopathy
Iodine
Transplants
Lung
Salivary Glands
Cardiomyopathies
Norepinephrine
Spleen
Liver

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Glowniak, J. V., Turner, F. E., Gray, L. L., Palac, R. T., Lagunas-Solar, M. C., & Woodward, W. (1989). Iodine-123 metaiodobenzylguanidine imaging of the heart in idiopathic congestive cardiomyopathy and cardiac transplants. Journal of Nuclear Medicine, 30(7), 1182-1191.

Iodine-123 metaiodobenzylguanidine imaging of the heart in idiopathic congestive cardiomyopathy and cardiac transplants. / Glowniak, J. V.; Turner, F. E.; Gray, L. L.; Palac, R. T.; Lagunas-Solar, M. C.; Woodward, William.

In: Journal of Nuclear Medicine, Vol. 30, No. 7, 1989, p. 1182-1191.

Research output: Contribution to journalArticle

Glowniak, JV, Turner, FE, Gray, LL, Palac, RT, Lagunas-Solar, MC & Woodward, W 1989, 'Iodine-123 metaiodobenzylguanidine imaging of the heart in idiopathic congestive cardiomyopathy and cardiac transplants', Journal of Nuclear Medicine, vol. 30, no. 7, pp. 1182-1191.
Glowniak, J. V. ; Turner, F. E. ; Gray, L. L. ; Palac, R. T. ; Lagunas-Solar, M. C. ; Woodward, William. / Iodine-123 metaiodobenzylguanidine imaging of the heart in idiopathic congestive cardiomyopathy and cardiac transplants. In: Journal of Nuclear Medicine. 1989 ; Vol. 30, No. 7. pp. 1182-1191.
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