Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

Scan M. Baker, Annemieke W. Plug, Tomas A. Prolla, C. Eric Bronner, Allie C. Harris, Xiang Yao, Donna Marie Christie, Craig Monell, Norm Arnheim, Allan Bradley, Terry Ashley, R. Michael Liskay

Research output: Contribution to journalArticle

634 Scopus citations

Abstract

Mice that are deficient in either the Pms2 or Msh2 DNA mismatch repair genes have microsatellite instability and a predisposition to tumours. Interestingly, Pms2-deficient males display sterility associated with abnormal chromosome pairing in meiosis. Here mice deficient in another mismatch repair gene, MIh1, possess not only microsatellite instability but are also infertile (both males and females). MIh1-deficient spermatocytes exhibit high levels of prematurely separated chromosomes and arrest in first division meiosis. We also show that MIh1 appears to localize to sites of crossing over on meiotic chromosomes. Together these findings suggest that MIh1 is involved in DNA mismatch repair and meiotic crossing over.

Original languageEnglish (US)
Pages (from-to)336-342
Number of pages7
JournalNature genetics
Volume13
Issue number3
DOIs
StatePublished - Jul 1996

ASJC Scopus subject areas

  • Genetics

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