Involvement of insula and cingulate cortices in control and suppression of natural urges

Alicja Lerner, Anto Bagic, Takashi Hanakawa, Eilis Boudreau, Fernando Pagan, Zoltan Mari, William Bara-Jimenez, Murat Aksu, Susumu Sato, Dennis L. Murphy, Mark Hallett

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The physiology of control and suppression of natural urges is not well understood. We used [15O]H2O positron-emission tomography imaging to identify neural circuits involved in suppression of spontaneous blinking as a model of normal urges. Suppression of blinking was associated with prominent activation of bilateral insular-claustrum regions, right more than left; activation was also found in bilateral anterior cingulate cortex (ACC), supplementary motor areas, and the face area of the primary motor cortex bilaterally. These results suggest a central role for the insula possibly together with ACC in suppression of blinking.

Original languageEnglish (US)
Pages (from-to)218-223
Number of pages6
JournalCerebral Cortex
Volume19
Issue number1
DOIs
StatePublished - Jan 2009

Fingerprint

Blinking
Gyrus Cinguli
Motor Cortex
Basal Ganglia
Positron-Emission Tomography

Keywords

  • Blinking
  • Insula
  • PET
  • Suppression
  • Urges
  • Visceral homunculus

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Involvement of insula and cingulate cortices in control and suppression of natural urges. / Lerner, Alicja; Bagic, Anto; Hanakawa, Takashi; Boudreau, Eilis; Pagan, Fernando; Mari, Zoltan; Bara-Jimenez, William; Aksu, Murat; Sato, Susumu; Murphy, Dennis L.; Hallett, Mark.

In: Cerebral Cortex, Vol. 19, No. 1, 01.2009, p. 218-223.

Research output: Contribution to journalArticle

Lerner, A, Bagic, A, Hanakawa, T, Boudreau, E, Pagan, F, Mari, Z, Bara-Jimenez, W, Aksu, M, Sato, S, Murphy, DL & Hallett, M 2009, 'Involvement of insula and cingulate cortices in control and suppression of natural urges', Cerebral Cortex, vol. 19, no. 1, pp. 218-223. https://doi.org/10.1093/cercor/bhn074
Lerner, Alicja ; Bagic, Anto ; Hanakawa, Takashi ; Boudreau, Eilis ; Pagan, Fernando ; Mari, Zoltan ; Bara-Jimenez, William ; Aksu, Murat ; Sato, Susumu ; Murphy, Dennis L. ; Hallett, Mark. / Involvement of insula and cingulate cortices in control and suppression of natural urges. In: Cerebral Cortex. 2009 ; Vol. 19, No. 1. pp. 218-223.
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