Involvement of endogenous orphanin FQ in electroacupuncture-induced analgesia

Jin Hua Tian, Wei Xu, Wei Zhang, Yuan Fang, Judith E. Grisel, Jeffrey S. Mogil, David K. Grandy, Ji Sheng Han

    Research output: Contribution to journalArticlepeer-review

    78 Scopus citations


    Recent studies suggest that the novel opioid peptide orphanin FQ (OFQ) is involved in pain modulation. We found that intracerebroventricular (i.c.v.) administration of OFQ in the rat produced a dose-dependent antagonism of the analgesia induced by 100 Hz electroacupuncture (EA) stimulation as measured in the radiant heat tail-flick assay. Antisense oligonucleotides injected i.c.v. potentiated EA analgesia, presumably by interfering with the expression of the OFQ receptor in brain. These results suggest that endogenous OFQ exerts a tonic antagonistic effect on EA-induced analgesia. No such antagonism was observed when OFQ was injected intrathecally (i.t.). Rather, it appears that spinal OFQ produced a marked analgesic effect and enhanced EA-induced analgesia. These findings are consistent with the experimental results obtained in rats where morphine-induced analgesia is antagonized by i.c.v. OFQ and potentiated by i.t. OFQ.

    Original languageEnglish (US)
    Pages (from-to)497-500
    Number of pages4
    Issue number2
    StatePublished - Jan 1 1997


    • Analgesia
    • Antisense oligodeoxynucleotide
    • Electroacupuncture-induced
    • LC132
    • Nociceptin
    • Opiate
    • Orphanin FQ
    • Pain inhibition

    ASJC Scopus subject areas

    • Neuroscience(all)


    Dive into the research topics of 'Involvement of endogenous orphanin FQ in electroacupuncture-induced analgesia'. Together they form a unique fingerprint.

    Cite this