Investigation on the Anticancer Activity of Symmetric and Unsymmetric Cyclic Sulfamides

Jaden Jungho Jun, Divya Duscharla, Ramesh Ummanni, Paul R. Hanson, Sanjay V. Malhotra

Research output: Contribution to journalArticlepeer-review

Abstract

The sulfamide functional group has been extensively employed in organic synthesis to discover probes and drugs in various applications such as cancer, human immunodeficiency virus (HIV), virus, and diabetes. Herein, we describe the synthesis of 7-membered symmetric and unsymmetric sulfamide compounds and their biological evaluation through the National Cancer Institute (NCI) panel of 60 human tumor cell lines (NCI-60) and the mechanism of action study. The results of a study from the NCI-60 cell line exhibited that many synthesized cyclic sulfamide compounds inhibited breast cancer (MDA-MB-468). The mechanism of action study of a representative compound 18 showed the inhibition of proliferation and apoptosis in A549 lung cancer cells.

Original languageEnglish (US)
Pages (from-to)202-210
Number of pages9
JournalACS Medicinal Chemistry Letters
Volume12
Issue number2
DOIs
StatePublished - Feb 11 2021

Keywords

  • A549 lung cancer
  • Anticancer activity
  • Cyclic sulfamide
  • NCI-60 cell line

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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