Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography

Ratheesh K. Meleppat; Myeong Jin Ju; Pengfei Zhang; Yifan Jian; Suman Manna; Daniel J. Wahl; Marinko V. Sarunic; Edward N. Pugh; Robert J. Zawadzki

doi:10.1117/12.2288739

Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography

Ratheesh K. Meleppat, Myeong Jin Ju, Pengfei Zhang, Yifan Jian, Suman Manna, Daniel J. Wahl, Marinko V. Sarunic, Edward N. Pugh, Robert J. Zawadzki

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Changes in visibility of the Henle fiber layer and photoreceptor bands of the human retina with illumination directionality have been reported in OCT clinical imaging. These are a direct consequence of the changes in back scattering due to fibrous tissue orientation and to waveguiding properties of the photoreceptors respectively. Here we report the preliminary results of a study on the effects of retinal images acquired with OCT of illumination directionality in the mouse retina. The quantitative assessment of the reflectivity of retinal layers of a BALB/c and WT pigmented mice was performed in-vivo using a swept-source optical coherence tomography system. The intensities of backscattered signals from different outer retinal layers were measured and compared.

Original language	English (US)
Title of host publication	Ophthalmic Technologies XXVIII
Editors	Arthur Ho, Per G. Soderberg, Fabrice Manns
Publisher	SPIE
ISBN (Electronic)	9781510614338
DOIs	https://doi.org/10.1117/12.2288739
State	Published - 2018
Externally published	Yes
Event	28th Conference on Ophthalmic Technologies - San Francisco, United States Duration: Jan 27 2018 → Jan 28 2018

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	10474
ISSN (Print)	1605-7422

Conference

Conference	28th Conference on Ophthalmic Technologies
Country/Territory	United States
City	San Francisco
Period	1/27/18 → 1/28/18

Keywords

Directional illumination
Optical coherence tomography
Retinal Imaging

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2288739

Cite this

Meleppat, R. K., Ju, M. J., Zhang, P., Jian, Y., Manna, S., Wahl, D. J., Sarunic, M. V., Pugh, E. N., & Zawadzki, R. J. (2018). Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography. In A. Ho, P. G. Soderberg, & F. Manns (Eds.), Ophthalmic Technologies XXVIII [104742B] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10474). SPIE. https://doi.org/10.1117/12.2288739

Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography. / Meleppat, Ratheesh K.; Ju, Myeong Jin; Zhang, Pengfei et al.

Ophthalmic Technologies XXVIII. ed. / Arthur Ho; Per G. Soderberg; Fabrice Manns. SPIE, 2018. 104742B (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10474).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Meleppat, RK, Ju, MJ, Zhang, P, Jian, Y, Manna, S, Wahl, DJ, Sarunic, MV, Pugh, EN & Zawadzki, RJ 2018, Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography. in A Ho, PG Soderberg & F Manns (eds), Ophthalmic Technologies XXVIII., 104742B, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10474, SPIE, 28th Conference on Ophthalmic Technologies, San Francisco, United States, 1/27/18. https://doi.org/10.1117/12.2288739

Meleppat RK, Ju MJ, Zhang P, Jian Y, Manna S, Wahl DJ et al. Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography. In Ho A, Soderberg PG, Manns F, editors, Ophthalmic Technologies XXVIII. SPIE. 2018. 104742B. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2288739

Meleppat, Ratheesh K. ; Ju, Myeong Jin ; Zhang, Pengfei et al. / Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography. Ophthalmic Technologies XXVIII. editor / Arthur Ho ; Per G. Soderberg ; Fabrice Manns. SPIE, 2018. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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abstract = "Changes in visibility of the Henle fiber layer and photoreceptor bands of the human retina with illumination directionality have been reported in OCT clinical imaging. These are a direct consequence of the changes in back scattering due to fibrous tissue orientation and to waveguiding properties of the photoreceptors respectively. Here we report the preliminary results of a study on the effects of retinal images acquired with OCT of illumination directionality in the mouse retina. The quantitative assessment of the reflectivity of retinal layers of a BALB/c and WT pigmented mice was performed in-vivo using a swept-source optical coherence tomography system. The intensities of backscattered signals from different outer retinal layers were measured and compared.",

keywords = "Directional illumination, Optical coherence tomography, Retinal Imaging",

author = "Meleppat, {Ratheesh K.} and Ju, {Myeong Jin} and Pengfei Zhang and Yifan Jian and Suman Manna and Wahl, {Daniel J.} and Sarunic, {Marinko V.} and Pugh, {Edward N.} and Zawadzki, {Robert J.}",

note = "Funding Information: Authors would like to acknowledge their funding sources: NSF I/UCRC CBSS Grant, NIH grants EY026556, and EY012576 (NEI Core Grant). This work was partially supported by Barr Retina Research Foundation gift to UC Davis Department of Ophthalmology. Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; 28th Conference on Ophthalmic Technologies ; Conference date: 27-01-2018 Through 28-01-2018",

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doi = "10.1117/12.2288739",

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AU - Meleppat, Ratheesh K.

AU - Ju, Myeong Jin

AU - Zhang, Pengfei

AU - Jian, Yifan

AU - Manna, Suman

AU - Wahl, Daniel J.

AU - Sarunic, Marinko V.

AU - Pugh, Edward N.

AU - Zawadzki, Robert J.

N1 - Funding Information: Authors would like to acknowledge their funding sources: NSF I/UCRC CBSS Grant, NIH grants EY026556, and EY012576 (NEI Core Grant). This work was partially supported by Barr Retina Research Foundation gift to UC Davis Department of Ophthalmology. Publisher Copyright: © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

PY - 2018

Y1 - 2018

N2 - Changes in visibility of the Henle fiber layer and photoreceptor bands of the human retina with illumination directionality have been reported in OCT clinical imaging. These are a direct consequence of the changes in back scattering due to fibrous tissue orientation and to waveguiding properties of the photoreceptors respectively. Here we report the preliminary results of a study on the effects of retinal images acquired with OCT of illumination directionality in the mouse retina. The quantitative assessment of the reflectivity of retinal layers of a BALB/c and WT pigmented mice was performed in-vivo using a swept-source optical coherence tomography system. The intensities of backscattered signals from different outer retinal layers were measured and compared.

AB - Changes in visibility of the Henle fiber layer and photoreceptor bands of the human retina with illumination directionality have been reported in OCT clinical imaging. These are a direct consequence of the changes in back scattering due to fibrous tissue orientation and to waveguiding properties of the photoreceptors respectively. Here we report the preliminary results of a study on the effects of retinal images acquired with OCT of illumination directionality in the mouse retina. The quantitative assessment of the reflectivity of retinal layers of a BALB/c and WT pigmented mice was performed in-vivo using a swept-source optical coherence tomography system. The intensities of backscattered signals from different outer retinal layers were measured and compared.

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Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography

Abstract

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Keywords

ASJC Scopus subject areas

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