Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography

Ratheesh K. Meleppat, Myeong Jin Ju, Pengfei Zhang, Yifan Jian, Suman Manna, Daniel J. Wahl, Marinko V. Sarunic, Edward N. Pugh, Robert J. Zawadzki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Changes in visibility of the Henle fiber layer and photoreceptor bands of the human retina with illumination directionality have been reported in OCT clinical imaging. These are a direct consequence of the changes in back scattering due to fibrous tissue orientation and to waveguiding properties of the photoreceptors respectively. Here we report the preliminary results of a study on the effects of retinal images acquired with OCT of illumination directionality in the mouse retina. The quantitative assessment of the reflectivity of retinal layers of a BALB/c and WT pigmented mice was performed in-vivo using a swept-source optical coherence tomography system. The intensities of backscattered signals from different outer retinal layers were measured and compared.

Original languageEnglish (US)
Title of host publicationOphthalmic Technologies XXVIII
EditorsArthur Ho, Per G. Soderberg, Fabrice Manns
PublisherSPIE
ISBN (Electronic)9781510614338
DOIs
StatePublished - Jan 1 2018
Externally publishedYes
Event28th Conference on Ophthalmic Technologies - San Francisco, United States
Duration: Jan 27 2018Jan 28 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10474
ISSN (Print)1605-7422

Conference

Conference28th Conference on Ophthalmic Technologies
CountryUnited States
CitySan Francisco
Period1/27/181/28/18

Keywords

  • Directional illumination
  • Optical coherence tomography
  • Retinal Imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography'. Together they form a unique fingerprint.

  • Cite this

    Meleppat, R. K., Ju, M. J., Zhang, P., Jian, Y., Manna, S., Wahl, D. J., Sarunic, M. V., Pugh, E. N., & Zawadzki, R. J. (2018). Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography. In A. Ho, P. G. Soderberg, & F. Manns (Eds.), Ophthalmic Technologies XXVIII [104742B] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10474). SPIE. https://doi.org/10.1117/12.2288739