Investigation of oxazine and rhodamine derivatives as peripheral nerve tissue targeting contrast agent for in Vivo fluorescence imaging

Lei G. Wang, Connor W. Barth, Jason R. Combs, Antonio R. Montaño, Summer L. Gibbs

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Accidental nerve transection or injury is a significant morbidity associated with many surgical interventions, resulting in persistent postsurgical numbness, chronic pain, and/or paralysis. Nervesparing can be a difficult task due to patient-To-patient variability and the difficulty of nerve visualization in the operating room. Fluorescence image-guided surgery to aid in the precise visualization of vital nerve structures in real time during surgery could greatly improve patient outcomes. To date, all nerve-specific contrast agents emit in the visible range. Developing a nearinfrared (NIR) nerve-specific fluorophore is poised to be a challenging task, as a NIR fluorophore must have enough "double-bonds" to reach the NIR imaging window, contradicting the requirement that a nerve-specific agent must have a relatively low molecular weight to cross the blood-nervebarrier (BNB). Herein we report our efforts to investigate the molecular characteristics for the nervespecific oxazine fluorophores, as well as their structurally analogous rhodamine fluorophores. Specifically, optical properties, physicochemical properties and their in vivo nerve specificity were evaluated herein.

Original languageEnglish (US)
Title of host publicationMolecular-Guided Surgery
Subtitle of host publicationMolecules, Devices, and Applications V
EditorsBrian W. Pogue, Sylvain Gioux
PublisherSPIE
ISBN (Electronic)9781510623668
DOIs
StatePublished - Jan 1 2019
EventMolecular-Guided Surgery: Molecules, Devices, and Applications V 2019 - San Francisco, United States
Duration: Feb 2 2019Feb 4 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10862
ISSN (Print)1605-7422

Conference

ConferenceMolecular-Guided Surgery: Molecules, Devices, and Applications V 2019
CountryUnited States
CitySan Francisco
Period2/2/192/4/19

Keywords

  • Contrast Agent
  • Fluorescence Imaging
  • Fluorophore
  • Image-Guided Surgery
  • Nerve.
  • Oxazine
  • Rhodamine

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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