Invadosomes are coming

New insights into function and disease relevance

Elyse K. Paterson, Sara Courtneidge

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Invadopodia and podosomes are discrete, actin-based molecular protrusions that form in cancer cells and normal cells, respectively, in response to diverse signaling pathways and extracellular matrix cues. Although they participate in a host of different cellular processes, they share a common functional theme of controlling pericellular proteolytic activity, which sets them apart from other structures that function in migration and adhesion, including focal adhesions, lamellipodia, and filopodia. In this review, we highlight research that explores the function of these complex structures, including roles for podosomes in embryonic and postnatal development, in angiogenesis and remodeling of the vasculature, in maturation of the postsynaptic membrane, in antigen sampling and recognition, and in cell-cell fusion mechanisms, as well as the involvement of invadopodia at multiple steps of the metastatic cascade, and how all of this may apply in the treatment of human disease states. Finally, we explore recent research that implicates a novel role for exosomes and microvesicles in invadopodia-dependent and invadopodia-independent mechanisms of invasion, respectively.

Original languageEnglish (US)
JournalFEBS Journal
DOIs
StateAccepted/In press - 2017

Fingerprint

Adhesion
Actins
Pseudopodia
Fusion reactions
Cells
Sampling
Membranes
Antigens
Exosomes
Focal Adhesions
Cell Fusion
Research
Embryonic Development
Cues
Extracellular Matrix
Podosomes
Neoplasms

Keywords

  • 3D growth
  • Degradation
  • F-actin
  • Invadopodia
  • Invadosome
  • Invasion
  • Metastasis
  • MT1-MMP
  • Podosomes
  • Tks5

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Invadosomes are coming : New insights into function and disease relevance. / Paterson, Elyse K.; Courtneidge, Sara.

In: FEBS Journal, 2017.

Research output: Contribution to journalArticle

@article{fdc55c05868946d19ca2b1e68871870d,
title = "Invadosomes are coming: New insights into function and disease relevance",
abstract = "Invadopodia and podosomes are discrete, actin-based molecular protrusions that form in cancer cells and normal cells, respectively, in response to diverse signaling pathways and extracellular matrix cues. Although they participate in a host of different cellular processes, they share a common functional theme of controlling pericellular proteolytic activity, which sets them apart from other structures that function in migration and adhesion, including focal adhesions, lamellipodia, and filopodia. In this review, we highlight research that explores the function of these complex structures, including roles for podosomes in embryonic and postnatal development, in angiogenesis and remodeling of the vasculature, in maturation of the postsynaptic membrane, in antigen sampling and recognition, and in cell-cell fusion mechanisms, as well as the involvement of invadopodia at multiple steps of the metastatic cascade, and how all of this may apply in the treatment of human disease states. Finally, we explore recent research that implicates a novel role for exosomes and microvesicles in invadopodia-dependent and invadopodia-independent mechanisms of invasion, respectively.",
keywords = "3D growth, Degradation, F-actin, Invadopodia, Invadosome, Invasion, Metastasis, MT1-MMP, Podosomes, Tks5",
author = "Paterson, {Elyse K.} and Sara Courtneidge",
year = "2017",
doi = "10.1111/febs.14123",
language = "English (US)",
journal = "FEBS Journal",
issn = "1742-464X",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Invadosomes are coming

T2 - New insights into function and disease relevance

AU - Paterson, Elyse K.

AU - Courtneidge, Sara

PY - 2017

Y1 - 2017

N2 - Invadopodia and podosomes are discrete, actin-based molecular protrusions that form in cancer cells and normal cells, respectively, in response to diverse signaling pathways and extracellular matrix cues. Although they participate in a host of different cellular processes, they share a common functional theme of controlling pericellular proteolytic activity, which sets them apart from other structures that function in migration and adhesion, including focal adhesions, lamellipodia, and filopodia. In this review, we highlight research that explores the function of these complex structures, including roles for podosomes in embryonic and postnatal development, in angiogenesis and remodeling of the vasculature, in maturation of the postsynaptic membrane, in antigen sampling and recognition, and in cell-cell fusion mechanisms, as well as the involvement of invadopodia at multiple steps of the metastatic cascade, and how all of this may apply in the treatment of human disease states. Finally, we explore recent research that implicates a novel role for exosomes and microvesicles in invadopodia-dependent and invadopodia-independent mechanisms of invasion, respectively.

AB - Invadopodia and podosomes are discrete, actin-based molecular protrusions that form in cancer cells and normal cells, respectively, in response to diverse signaling pathways and extracellular matrix cues. Although they participate in a host of different cellular processes, they share a common functional theme of controlling pericellular proteolytic activity, which sets them apart from other structures that function in migration and adhesion, including focal adhesions, lamellipodia, and filopodia. In this review, we highlight research that explores the function of these complex structures, including roles for podosomes in embryonic and postnatal development, in angiogenesis and remodeling of the vasculature, in maturation of the postsynaptic membrane, in antigen sampling and recognition, and in cell-cell fusion mechanisms, as well as the involvement of invadopodia at multiple steps of the metastatic cascade, and how all of this may apply in the treatment of human disease states. Finally, we explore recent research that implicates a novel role for exosomes and microvesicles in invadopodia-dependent and invadopodia-independent mechanisms of invasion, respectively.

KW - 3D growth

KW - Degradation

KW - F-actin

KW - Invadopodia

KW - Invadosome

KW - Invasion

KW - Metastasis

KW - MT1-MMP

KW - Podosomes

KW - Tks5

UR - http://www.scopus.com/inward/record.url?scp=85021259205&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021259205&partnerID=8YFLogxK

U2 - 10.1111/febs.14123

DO - 10.1111/febs.14123

M3 - Article

JO - FEBS Journal

JF - FEBS Journal

SN - 1742-464X

ER -