Intrinsic neurons in the rat ovary: An immunohistochemical study

Hortensia D'Albora, Paula Lombide, Sergio Ojeda

    Research output: Contribution to journalArticle

    41 Citations (Scopus)

    Abstract

    Previous studies have shown the presence of neuronal perikarya in the primate ovary, but not in the ovary from Sprague-Dawley rats. We report here that while such intrinsic neurons are indeed absent in this strain of rats, they can be visualized in the ovary from Wistar rats. The neurons, identified by their morphology and by the expression of NeuN (a neuron-specific nuclear protein), were detected at all postnatal intervals examined, from 14 h after birth to 50 days of age. While they were present in the ovarian hilum and medulla at all ages studied, neurons first appeared in the ovarian cortex during the juvenile period (postnatal days 10-20). In all cases, the size of the neuronal soma increased significantly during prepubertal development, reaching maximal values before puberty. Some neurons were catecholaminergic, as indicated by their content of immunoreactyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis. Some showed neuropeptide Y (NPY) immunoreactivity. TH-positive neurons were seen either in isolation or clustered in ganglion-like structures in both the ovarian cortex and medulla. These results indicate that ovarian neurons are not present in all strains of rats, but when present, the chemical phenotype of some of them is of a sympathetic nature, similar to that described in primates.

    Original languageEnglish (US)
    Pages (from-to)47-56
    Number of pages10
    JournalCell and Tissue Research
    Volume300
    Issue number1
    DOIs
    StatePublished - 2000

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    Neurons
    Rats
    Ovary
    Primates
    Neuropeptide Y
    Biosynthesis
    Carisoprodol
    Puberty
    Nuclear Proteins
    Mixed Function Oxygenases
    Ganglia
    Catecholamines
    Sprague Dawley Rats
    Wistar Rats
    Parturition
    Phenotype
    Enzymes

    Keywords

    • Neuron specific
    • Neuropeptide Y
    • Nuclear protein
    • Ovarian innervation
    • Rat (Wistar; Sprague-Dawley)
    • Tyrosine hydroxylase

    ASJC Scopus subject areas

    • Anatomy
    • Clinical Biochemistry
    • Cell Biology

    Cite this

    Intrinsic neurons in the rat ovary : An immunohistochemical study. / D'Albora, Hortensia; Lombide, Paula; Ojeda, Sergio.

    In: Cell and Tissue Research, Vol. 300, No. 1, 2000, p. 47-56.

    Research output: Contribution to journalArticle

    D'Albora, Hortensia ; Lombide, Paula ; Ojeda, Sergio. / Intrinsic neurons in the rat ovary : An immunohistochemical study. In: Cell and Tissue Research. 2000 ; Vol. 300, No. 1. pp. 47-56.
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