Intrinsic horizontal connections process global tactile features in the primary somatosensory cortex

Neuroanatomical evidence

László Négyessy, Emese Pálfi, Mária Ashaber, Cory Palmer, Balázs Jákli, Robert M. Friedman, Li M. Chen, Anna Roe

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

To understand manual tactile functions in primates, it is essential to explore the interactions between the finger pad representations in somatosensory cortex. To this end, we used optical imaging and electrophysiological mapping to guide neuroanatomical tracer injections into distal digit tip representations of Brodmann area 3b in the squirrel monkey. Retrogradely labeled cell densities and anterogradely labeled fibers and terminal patches in somatosensory areas were plotted and quantified with respect to tangential distribution. Within area 3b, reciprocal patchy distribution of anterograde and retrograde labeling spanned the representation of the distal pad of multiple digits, indicating strong cross-digit connectivity. Inter-areal connections revealed bundles of long-range fibers projecting anteroposteriorly, connecting area 3b with clusters of labeled neurons and terminal axon arborizations in area 1. Inter-areal linkage appeared to be largely confined to the representation of the injected finger. These findings provide the neuroanatomical basis for the interaction between distal finger pad representations observed by recent electrophysiological studies. We propose that intra-areal connectivity may be heavily involved in interdigit integration such as shape discrimination, whereas long-range inter-areal connections may subserve active touch in a digit-specific manner. J. Comp. Neurol. 521:2798-2817, 2013.

Original languageEnglish (US)
Pages (from-to)2798-2817
Number of pages20
JournalJournal of Comparative Neurology
Volume521
Issue number12
DOIs
StatePublished - Aug 15 2013
Externally publishedYes

Fingerprint

Somatosensory Cortex
Touch
Fingers
Saimiri
Optical Imaging
Presynaptic Terminals
Primates
Cell Count
Neurons
Injections

Keywords

  • Finger pad
  • Optical imaging
  • Primate
  • Touch
  • Tract tracing

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Intrinsic horizontal connections process global tactile features in the primary somatosensory cortex : Neuroanatomical evidence. / Négyessy, László; Pálfi, Emese; Ashaber, Mária; Palmer, Cory; Jákli, Balázs; Friedman, Robert M.; Chen, Li M.; Roe, Anna.

In: Journal of Comparative Neurology, Vol. 521, No. 12, 15.08.2013, p. 2798-2817.

Research output: Contribution to journalArticle

Négyessy, László ; Pálfi, Emese ; Ashaber, Mária ; Palmer, Cory ; Jákli, Balázs ; Friedman, Robert M. ; Chen, Li M. ; Roe, Anna. / Intrinsic horizontal connections process global tactile features in the primary somatosensory cortex : Neuroanatomical evidence. In: Journal of Comparative Neurology. 2013 ; Vol. 521, No. 12. pp. 2798-2817.
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