Intrinsic differences between oral and skin keratinocytes

Anna Turabelidze; Shujuan Guo; Allison Yen Chung; Lin Chen; Yang Dai; Phillip T. Marucha; Luisa A. DiPietro

doi:10.1371/journal.pone.0101480

Intrinsic differences between oral and skin keratinocytes

Anna Turabelidze, Shujuan Guo, Allison Yen Chung, Lin Chen, Yang Dai, Phillip T. Marucha, Luisa A. DiPietro

School of Dentistry

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Keratinocytes cover both the skin and some oral mucosa, but the morphology of each tissue and the behavior of the keratinocytes from these two sites are different. One significant dissimilarity between the two sites is the response to injury. Oral mucosal wounds heal faster and with less inflammation than equivalent cutaneous wounds. We hypothesized that oral and skin keratinocytes might have intrinsic differences at baseline as well as in the response to injury, and that such differences would be reflected in gene expression profiles.

Original language	English (US)
Article number	e101480
Journal	PloS one
Volume	9
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0101480
State	Published - Sep 8 2014

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AU - Dai, Yang

AU - Marucha, Phillip T.

AU - DiPietro, Luisa A.

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Intrinsic differences between oral and skin keratinocytes

Abstract

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