Intrinsic differences between oral and skin keratinocytes

Anna Turabelidze, Shujuan Guo, Allison Yen Chung, Lin Chen, Yang Dai, Phillip T. Marucha, Luisa A. DiPietro

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Keratinocytes cover both the skin and some oral mucosa, but the morphology of each tissue and the behavior of the keratinocytes from these two sites are different. One significant dissimilarity between the two sites is the response to injury. Oral mucosal wounds heal faster and with less inflammation than equivalent cutaneous wounds. We hypothesized that oral and skin keratinocytes might have intrinsic differences at baseline as well as in the response to injury, and that such differences would be reflected in gene expression profiles.

Original languageEnglish (US)
Article numbere101480
JournalPloS one
Volume9
Issue number9
DOIs
StatePublished - Sep 8 2014

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Turabelidze, A., Guo, S., Chung, A. Y., Chen, L., Dai, Y., Marucha, P. T., & DiPietro, L. A. (2014). Intrinsic differences between oral and skin keratinocytes. PloS one, 9(9), [e101480]. https://doi.org/10.1371/journal.pone.0101480