Intravenous vasopressin infusion decreases plasma ACTH concentration in conscious dogs

Virginia Brooks, L. J. Blakemore, L. C. Keil

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Vasopressin infusion increases arterial and atrial pressures, which could stimulate arterial and cardiac baroreceptors to inhibit adrenocortotropin (ACTH) secretion. Therefore, the current experiments were performed to test the hypothesis that vasopressin infusion decreases plasma ACTH concentration in conscious dogs. Vasopressin was infused for 90 min in three doses (0.5, 1.0, and 2.0 ng·kg-1·min-1) that produced increases in plasma levels within the physiological range. Only the highest dose of vasopressin increased mean arterial; pressure, but left atrial pressure increased with all doses, and right atrial pressure increased with the two highest doses. A bradycardia was produced with all doses of vasopressin. Plasma ACTH concentration decreased from 44 ± 12 to 25 ± 7 (P <0.01), from 50 ± 11 to 26 ± 9 (P <0.001), and from 70 ± 15 to28 ± 4 pg/ml (P <0.001) with infusion of 0.5, 1.0, and 2.0 ng·kg-1·min-1 vasopressin, respectively. In contrast, plasma cortisol concentration first increased (P <0.05) with each vasopressin dose, but after 15-30 min it decreased back to control levels. These results demonstrate that intravenous infusion of vasopressin decreases plasma ACTH concentration. Because the inhibition is associated with increases in atrial pressure and decreases in heart rate, it may be mediated via activation of the baroreceptor reflex.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume255
Issue number4
StatePublished - 1988

Fingerprint

Vasopressins
Intravenous Infusions
Adrenocorticotropic Hormone
Dogs
Atrial Pressure
Pressoreceptors
Baroreflex
Bradycardia
Hydrocortisone
Arterial Pressure
Heart Rate
Pressure

ASJC Scopus subject areas

  • Physiology

Cite this

@article{9a1cd1d453f9485dba3457b7fdd85a8e,
title = "Intravenous vasopressin infusion decreases plasma ACTH concentration in conscious dogs",
abstract = "Vasopressin infusion increases arterial and atrial pressures, which could stimulate arterial and cardiac baroreceptors to inhibit adrenocortotropin (ACTH) secretion. Therefore, the current experiments were performed to test the hypothesis that vasopressin infusion decreases plasma ACTH concentration in conscious dogs. Vasopressin was infused for 90 min in three doses (0.5, 1.0, and 2.0 ng·kg-1·min-1) that produced increases in plasma levels within the physiological range. Only the highest dose of vasopressin increased mean arterial; pressure, but left atrial pressure increased with all doses, and right atrial pressure increased with the two highest doses. A bradycardia was produced with all doses of vasopressin. Plasma ACTH concentration decreased from 44 ± 12 to 25 ± 7 (P <0.01), from 50 ± 11 to 26 ± 9 (P <0.001), and from 70 ± 15 to28 ± 4 pg/ml (P <0.001) with infusion of 0.5, 1.0, and 2.0 ng·kg-1·min-1 vasopressin, respectively. In contrast, plasma cortisol concentration first increased (P <0.05) with each vasopressin dose, but after 15-30 min it decreased back to control levels. These results demonstrate that intravenous infusion of vasopressin decreases plasma ACTH concentration. Because the inhibition is associated with increases in atrial pressure and decreases in heart rate, it may be mediated via activation of the baroreceptor reflex.",
author = "Virginia Brooks and Blakemore, {L. J.} and Keil, {L. C.}",
year = "1988",
language = "English (US)",
volume = "255",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "4",

}

TY - JOUR

T1 - Intravenous vasopressin infusion decreases plasma ACTH concentration in conscious dogs

AU - Brooks, Virginia

AU - Blakemore, L. J.

AU - Keil, L. C.

PY - 1988

Y1 - 1988

N2 - Vasopressin infusion increases arterial and atrial pressures, which could stimulate arterial and cardiac baroreceptors to inhibit adrenocortotropin (ACTH) secretion. Therefore, the current experiments were performed to test the hypothesis that vasopressin infusion decreases plasma ACTH concentration in conscious dogs. Vasopressin was infused for 90 min in three doses (0.5, 1.0, and 2.0 ng·kg-1·min-1) that produced increases in plasma levels within the physiological range. Only the highest dose of vasopressin increased mean arterial; pressure, but left atrial pressure increased with all doses, and right atrial pressure increased with the two highest doses. A bradycardia was produced with all doses of vasopressin. Plasma ACTH concentration decreased from 44 ± 12 to 25 ± 7 (P <0.01), from 50 ± 11 to 26 ± 9 (P <0.001), and from 70 ± 15 to28 ± 4 pg/ml (P <0.001) with infusion of 0.5, 1.0, and 2.0 ng·kg-1·min-1 vasopressin, respectively. In contrast, plasma cortisol concentration first increased (P <0.05) with each vasopressin dose, but after 15-30 min it decreased back to control levels. These results demonstrate that intravenous infusion of vasopressin decreases plasma ACTH concentration. Because the inhibition is associated with increases in atrial pressure and decreases in heart rate, it may be mediated via activation of the baroreceptor reflex.

AB - Vasopressin infusion increases arterial and atrial pressures, which could stimulate arterial and cardiac baroreceptors to inhibit adrenocortotropin (ACTH) secretion. Therefore, the current experiments were performed to test the hypothesis that vasopressin infusion decreases plasma ACTH concentration in conscious dogs. Vasopressin was infused for 90 min in three doses (0.5, 1.0, and 2.0 ng·kg-1·min-1) that produced increases in plasma levels within the physiological range. Only the highest dose of vasopressin increased mean arterial; pressure, but left atrial pressure increased with all doses, and right atrial pressure increased with the two highest doses. A bradycardia was produced with all doses of vasopressin. Plasma ACTH concentration decreased from 44 ± 12 to 25 ± 7 (P <0.01), from 50 ± 11 to 26 ± 9 (P <0.001), and from 70 ± 15 to28 ± 4 pg/ml (P <0.001) with infusion of 0.5, 1.0, and 2.0 ng·kg-1·min-1 vasopressin, respectively. In contrast, plasma cortisol concentration first increased (P <0.05) with each vasopressin dose, but after 15-30 min it decreased back to control levels. These results demonstrate that intravenous infusion of vasopressin decreases plasma ACTH concentration. Because the inhibition is associated with increases in atrial pressure and decreases in heart rate, it may be mediated via activation of the baroreceptor reflex.

UR - http://www.scopus.com/inward/record.url?scp=0023793382&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023793382&partnerID=8YFLogxK

M3 - Article

C2 - 2845823

AN - SCOPUS:0023793382

VL - 255

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 4

ER -