Intravascular cooling in the treatment of stroke (ICTuS)

Early clinical experience

Patrick D. Lyden, Robin L. Allgren, Ken Ng, Paul Akins, Brett Meyer, Fahmi Al-Sanani, Helmi Lutsep, John Dobak, Bradley S. Matsubara, Justin Zivin

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

We sought to evaluate the safety and feasibility of mild therapeutic hypothermia using an endovascular temperature management system in awake acute ischemic stroke patients. The Intravascular Cooling in the Treatment of Stroke (ICTuS) study was an uncontrolled, multicenter development and feasibility study of conscious patients (n = 18) presenting within 12 hours of onset of an acute ischemic stroke at 5 clinical sites in the United States. Enrolled patients were to undergo core temperature management using an endovascular cooling system to induce and maintain mild, therapeutic hypothermia (target temperature of 33.0°C) for a period of either 12 or 24 hours, followed by controlled rewarming to 36.5°C over the subsequent 12-hour period. Nine patients underwent 12 hours of cooling followed by 12 hours of controlled rewarming, and 6 patients underwent 24 hours of cooling followed by 12 hours of controlled rewarming. Three patients underwent

Original languageEnglish (US)
Pages (from-to)107-114
Number of pages8
JournalJournal of Stroke and Cerebrovascular Diseases
Volume14
Issue number3
DOIs
StatePublished - May 2005

Fingerprint

Stroke
Rewarming
Induced Hypothermia
Temperature
Therapeutics
Feasibility Studies
Multicenter Studies
Safety

Keywords

  • Clinical trial
  • Hypothermia
  • Stroke
  • Thrombolysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Health Professions(all)

Cite this

Intravascular cooling in the treatment of stroke (ICTuS) : Early clinical experience. / Lyden, Patrick D.; Allgren, Robin L.; Ng, Ken; Akins, Paul; Meyer, Brett; Al-Sanani, Fahmi; Lutsep, Helmi; Dobak, John; Matsubara, Bradley S.; Zivin, Justin.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 14, No. 3, 05.2005, p. 107-114.

Research output: Contribution to journalArticle

Lyden, PD, Allgren, RL, Ng, K, Akins, P, Meyer, B, Al-Sanani, F, Lutsep, H, Dobak, J, Matsubara, BS & Zivin, J 2005, 'Intravascular cooling in the treatment of stroke (ICTuS): Early clinical experience', Journal of Stroke and Cerebrovascular Diseases, vol. 14, no. 3, pp. 107-114. https://doi.org/10.1016/j.jstrokecerebrovasdis.2005.01.001
Lyden, Patrick D. ; Allgren, Robin L. ; Ng, Ken ; Akins, Paul ; Meyer, Brett ; Al-Sanani, Fahmi ; Lutsep, Helmi ; Dobak, John ; Matsubara, Bradley S. ; Zivin, Justin. / Intravascular cooling in the treatment of stroke (ICTuS) : Early clinical experience. In: Journal of Stroke and Cerebrovascular Diseases. 2005 ; Vol. 14, No. 3. pp. 107-114.
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