Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a doubleclad fiber combiner

Shanshan Liang, Arya Saidi, Joe Jing, Gangjun Liu, Jiawen Li, Jun Zhang, Changsen Sun, Jagat Narula, Zhongping Chen

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

We developed a multimodality fluorescence and optical coherence tomography probe based on a doubleclad fiber (DCF) combiner. The probe is composed of a DCF combiner, grin lens, and micromotor in the distal end. An integrated swept-source optical coherence tomography and fluorescence intensity imaging system was developed based on the combined probe for the early diagnoses of atherosclerosis. This system is capable of real-time data acquisition and processing as well as image display. For fluorescence imaging, the inflammation of atherosclerosis and necrotic core formed with the annexin V-conjugated Cy5.5 were imaged. Ex vivo imaging of New Zealand white rabbit arteries demonstrated the capability of the combined system.

Original languageEnglish (US)
Article number070501
JournalJournal of biomedical optics
Volume17
Issue number7
DOIs
StatePublished - 2012

Keywords

  • Annexin V
  • Atherogenesis
  • Double-clad fiber
  • Fluorescence
  • Optical coherence tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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