Intrauterine lidocaine infusion for pain management during outpatient transcervical tubal sterilization: A randomized controlled trial

Michelle M. Isley, Jeffrey T. Jensen, Mark D. Nichols, Amy Lehman, Paula Bednarek, Alison Edelman

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background: The study was conducted to examine the effects of a 4% intrauterine lidocaine infusion on patient-perceived pain during transcervical sterilization. Study Design: This was a randomized, double-blind, placebo-controlled trial. Subjects received standard premedication with 800 mg ibuprofen, 2 mg lorazepam, a 10-mL 1% lidocaine paracervical block and transcervical instillation of 5 mL of either 4% lidocaine or saline 3 min prior to insertion of the hysteroscope. Subjects completed a series of 100-mm visual analog scales to measure their perceived pain at set time points during and after the procedure. Serum lidocaine levels were obtained in a subset of subjects. Results: Pain scores at all evaluation points did not significantly differ between groups (lidocaine n=29, saline n=29). Mean lidocaine levels did not differ between groups, and no subject demonstrated symptoms of lidocaine toxicity. The highest serum lidocaine level (4022 ng/mL) occurred 20 min after infusion in a lidocaine-treated subject. Conclusion: Intrauterine lidocaine prior to outpatient transcervical sterilization does not decrease pain.

Original languageEnglish (US)
Pages (from-to)275-281
Number of pages7
JournalContraception
Volume85
Issue number3
DOIs
StatePublished - Mar 1 2012

Keywords

  • Hysteroscopic transcervical sterilization
  • Intrauterine lidocaine
  • Pain
  • Sterilization

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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