Intrauterine insemination outperforms intracervical insemination in a randomized, controlled study with frozen, donor semen

P. E. Patton, K. A. Burry, A. Thurmond, M. J. Novy, D. P. Wolf

Research output: Contribution to journalArticle

51 Scopus citations


Objective: To assess the efficacy of intrauterine insemination (IUI) in a donor insemination program. Design: Prospective randomized clinical trial. Setting: Donor insemination program. Patients, Participants: Women undergoing insemination were randomly assigned to receive either IUI or intracervical insemination for a maximum of six cycles. Interventions: None. Main Outcome Measure(s): Cycle fecundity rates between the two routes were compared. Results: The monthly fecundity rate for intracervical insemination was 5.1% compared with 23% by IUI. By life table analysis, pregnancy rates for IUI were significantly higher than intracervical insemination (P = 0.02). Conclusions: Intrauterine insemination with quarantined donor sperm is superior to intracervical insemination.

Original languageEnglish (US)
Pages (from-to)559-564
Number of pages6
JournalFertility and sterility
Issue number3
StatePublished - Jan 1 1992



  • Route of insemination
  • intrauterine insemination with frozen donor semen

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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