Intrauterine administration of CDB-2914 (Ulipristal) suppresses the endometrium of rhesus macaques

Robert M. Brenner, Ov Slayden, Anita Nath, Y. Y. Tsong, Regine Sitruk-Ware

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    Background: Ulipristal (UPA; CDB-2914) is a progesterone receptor modulator with contraceptive potential. To test its effects when delivered by an intrauterine system (IUS), we prepared control and UPA-filled IUS and evaluated their effects in rhesus macaques. Study Design: Short lengths of Silastic tubing either empty (n=3) or containing UPA (n=5) were inserted into the uteri of 8 ovariectomized macaques. Animals were cycled by sequential treatment with estradiol and progesterone. After 3.5 cycles, the uterus was removed. Results: During treatment, animals with an empty IUS menstruated for a mean total of 11.66±0.88 days, while UPA-IUS treated animals bled for only 1±0.45 days. Indices of endometrial proliferation were significantly reduced by UPA-IUS treatment. The UPA exposed endometria were atrophied with some glandular cysts while the blank controls displayed a proliferative morphology without cysts. Androgen receptors were more intensely stained in the glands of the UPA-IUS treated endometria than in the blank-IUS treated controls. Conclusions: In rhesus macaques, a UPA-IUS induced endometrial atrophy and amenorrhea. The work provides proof of principle that an IUS can deliver effective intrauterine concentrations of Ulipristal.

    Original languageEnglish (US)
    Pages (from-to)336-342
    Number of pages7
    JournalContraception
    Volume81
    Issue number4
    DOIs
    StatePublished - Apr 2010

    Fingerprint

    Endometrium
    Macaca mulatta
    Uterus
    Cysts
    Amenorrhea
    Androgen Receptors
    Macaca
    Progesterone Receptors
    Contraceptive Agents
    Atrophy
    Progesterone
    Estradiol
    ulipristal

    Keywords

    • CDB-2914
    • Endometrium
    • Intrauterine
    • Rhesus macaque
    • Ulipristal

    ASJC Scopus subject areas

    • Reproductive Medicine
    • Obstetrics and Gynecology

    Cite this

    Intrauterine administration of CDB-2914 (Ulipristal) suppresses the endometrium of rhesus macaques. / Brenner, Robert M.; Slayden, Ov; Nath, Anita; Tsong, Y. Y.; Sitruk-Ware, Regine.

    In: Contraception, Vol. 81, No. 4, 04.2010, p. 336-342.

    Research output: Contribution to journalArticle

    Brenner, Robert M. ; Slayden, Ov ; Nath, Anita ; Tsong, Y. Y. ; Sitruk-Ware, Regine. / Intrauterine administration of CDB-2914 (Ulipristal) suppresses the endometrium of rhesus macaques. In: Contraception. 2010 ; Vol. 81, No. 4. pp. 336-342.
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